Volume 14, Number 3—March 2008
Research
Hantavirus RNA in Saliva from Patients with Hemorrhagic Fever with Renal Syndrome
Lisa Pettersson*, Jonas Klingström*†‡, Jonas Hardestam†‡, Åke Lundkvist†‡, Clas Ahlm*, and Magnus Evander*
Table
Comparison between detection of PUUV RNA in saliva and plasma and antibodies in serum samples from 14 patients with nephropathia epidemica*
| Patient no. | Sex | Age, y | Date saliva collected (d of disease) | PUUV RNA† in saliva, copies/mL | PUUV RNA† in plasma,‡ copies/mL | PUUV IgM§ in serum‡ | PUUV IgG titer in serum‡ |
|---|---|---|---|---|---|---|---|
| 1 | M | 65 | 6 | 121,323 | 959,294 | + | 40 |
| 2 | M | 64 | 2 | 66,994 | 117,562 | + | 80 |
| 3 | M | 33 | 5 | 44,898 | 40,427 | + | >640 |
| 4 | F | 38 | 6 | 17,516 | 1,381,413 | + | 40 |
| 5 | F | 59 | 9 | 9,582 | 3,724 | + | >640 |
| 6 | M | 54 | 5 | 6,372 | 26,626 | – | 320 |
| 7 | M | 39 | 7 | 3,745 | 189,233 | + | 320 |
| 8 | M | 28 | 5 | 2,589 | 36,231 | + | >640 |
| 9 | F | 26 | 5 | 2,163 | 54,315 | + | 80 |
| 10 | F | 39 | 5 | 1,530 | 3,044 | + | 80 |
| 11 | M | 38 | 6 | 0 | 1,952 | ± | >640 |
| 12 | M | 41 | 6 | 0 | 5,215 | + | 40 |
| 13 | F | 57 | 2 | 0 | 41,271 | + | 320 |
| 14 | F | 62 | 7 | 0 | 81,330 | + | 160 |
*PUUV, Puumala virus; Ig, immunoglobulin.
†Detected by real-time reverse transcription–PCR.
‡Most plasma and serum samples were collected the same day or within 1 day before or after the saliva sample and antibody was detected by immunofluorescence assay.
§Serum was diluted 1:16 and scored as negative (–), positive (+), or weakly positive (±).
Page created: July 07, 2010
Page updated: July 07, 2010
Page reviewed: July 07, 2010
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.