Volume 16, Number 3—March 2010
Research
Invasive Haemophilus influenzae Disease, Europe, 1996–2006
, Mary P.E. Slack, Paul T. Heath, Anne von Gottberg, Manosree Chandra, Mary E. Ramsay, and European Union Invasive Bacterial Infection Surveillance participants1
Table 2
Hib and ncHi cases, by diagnosis and age group, Europe 1996–2006*
| Diagnosis | Age group |
NR | Total | Median age, y | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| <1 mo | 1–5 mo | 6–11 mo | <1 y | 1–4 y | 5–14 y | 15–44 y | 45–64 y | >65 y | ||||
| Hib | ||||||||||||
| Meningitis | 6 (31.6) | 93 (60.4) | 98 (57.6) | 197 (57.4) | 282 (41.2) | 45 (23.0) | 26 (10.0) | 17 (7.1) | 12 (4.4) | 1 (12.5) | 580 (28.9) | 1.6 |
| Epiglottitis | 0 | 1 (0.6) | 4 (2.4) | 5 (1.5) | 110 (16.1) | 29 (14.8) | 45 (17.4) | 37 (15.4) | 22 (8.0) | 0 | 248 (12.4) | 6.7 |
| Cellulitis | 0 | 7 (4.5) | 18 (10.6) | 25 (7.3) | 15 (2.2) | 3 (1.5) | 0 | 1 (0.4) | 4 (1.5) | 0 | 48 (2.4) | 1.0 |
| OM/SA | 0 | 4 (2.6) | 5 (2.9) | 9 (2.6) | 24 (3.5) | 4 (2.0) | 4 (1.5) | 6 (2.5) | 1 (0.4) | 0 | 48 (2.4) | 2.1 |
| Pneumonia | 0 | 3 (1.9) | 5 (2.9) | 8 (2.3) | 20 (2.9) | 15 (7.7) | 35 (13.5) | 36 (14.9) | 47 (17.2) | 1 (12.5) | 162 (8.1) | 46.7 |
| Bacteremia | 11 (57.9) | 33 (21.4) | 30 (17.6) | 74 (21.6) | 193 (28.2) | 73 (37.2) | 102 (39.4) | 96 (39.8) | 134 (48.9) | 2 (25.0) | 674 (33.6) | 13.6 |
| Other | 0 | 1 (0.6) | 2 (1.2) | 3 (0.9) | 10 (1.5) | 6 (3.1) | 10 (3.9) | 11 (4.6) | 7 (2.6) | 0 | 47 (2.3) | 34.6 |
| NR | 2 (10.5) | 12 (7.8) | 8 (4.7) | 22 (6.4) | 30 (4.4) | 21 (10.7) | 37 (14.3) | 37 (15.4) | 47 (17.2) | 4 (50.0) | 198 (9.9) | 39.0 |
| All cases |
19 (100.0) |
154 (100.0) |
170 (100.0) |
343 (100.0) |
684 (100.0) |
196 (100.0) |
259 (100.0) |
241 (100.0) |
274 (100.0) |
8 (100.0) |
2005 (100.0) |
4.5 |
| ncHi | ||||||||||||
| Meningitis | 8 (4.4) | 15 (13.6) | 19 (19.4) | 42 (10.8) | 76 (22.6) | 37 (24.2) | 65 (14.3) | 63 (13.6) | 45 (3.3) | 4 (20.0) | 332 (10.5) | 19.7 |
| Epiglottitis | 2 (1.1) | 0 | 0 | 2 (0.5) | 2 (0.6) | 1 (0.7) | 5 (1.1) | 5 (1.1) | 3 (0.2) | 0 | 18 (0.6) | 42.1 |
| Cellulitis | 0 | 0 | 1 (1.0) | 1 (0.3) | 4 (1.2) | 5 (3.3) | 0 | 0 | 4 (0.3) | 0 | 14 (0.4) | 11.6 |
| OM/SA | 0 | 0 | 0 | 0 | 2 (0.6) | 1 (0.7) | 2 (0.4) | 2 (0.4) | 4 (0.3) | 0 | 11 (0.3) | 56.6 |
| Pneumonia | 10 (5.5) | 14 (12.7) | 11 (11.2) | 35 (9.0) | 39 (11.6) | 11 (7.2) | 34 (7.5) | 56 (12.1) | 226 (16.7) | 0 | 401 (12.6) | 70.0 |
| Bacteremia | 129 (70.9) | 53 (48.2) | 46 (46.9) | 228 (58.5) | 151 (44.8) | 74 (48.4) | 236 (52.0) | 218 (47.0) | 759 (56.1) | 10 (50.0) | 1,676 (52.8) | 59.6 |
| Other | 3 (1.6) | 8 (7.3) | 8 (8.2) | 19 (4.9) | 21 (6.2) | 5 (3.3) | 20 (4.4) | 9 (1.9) | 38 (2.8) | 2 (10.0) | 114 (3.6) | 31.2 |
| NR | 30 (16.5) | 20 (18.2) | 13 (13.3) | 63 (16.2) | 42 (12.5) | 19 (12.4) | 92 (20.3) | 111 (23.9) | 275 (20.3) | 4 (20.0) | 606 (19.1) | 61.3 |
| All cases | 182 (100.0) | 110 (100.0) | 98 (100.0) | 390 (100.0) | 337 (100.0) | 153 (100.0) | 454 (100.0) | 464 (100.0) | 1354 (100.0) | 20 (100.0) | 3,172 (100.0) | 58.2 |
*Pediatric cases only for Attiki, Greece (1996–2002); Germany (1998 onward); and Israel (1996 onward). Values are no. (%) cases except as indicated. Hib, Haemophilus influenzae type b; ncHi, noncapsulated H. influenzae; NR, not recorded; OM/SA, osteomyelitis/septic arthritis.
1European Union Invasive Bacterial Infection Surveillance participants: Peter McIntyre, Lyn Gilbert, Geoff Hogg (Australia); Reinhild Strauss, Sigrid Heuberger (Austria); Germaine Hanquet, Francoise Crokaert (Belgium); Pavla Krizova, Vera Lebedova (Czech Republic); Kåre Mølbak, Jens Jørgen Christensen (Denmark); Kuulo Kutsar, Unna Joks (Estonia); Elja Herva, Tarja Kaijalainen, Maija Leinonen, Petri Ruutu (Finland); Agnes Lepoutre, Henri Dabernat (France); Anette Siedler, Heinz-J. Schmitt (Germany); Marie Theodoridou, Anastasia Pangalis, Georgina Tzanakaki (Greece); Miklos Fuzi, Katalin Krisztalovics (Hungary); Thorolfur Gudnason, Hjordis Hardardottir (Iceland); Mary Cafferkey, Suzanne Cotter, Darina O'Flanagan (Republic of Ireland); Ron Dagan (Israel); Marina Cerquetti, Marta Ciofi degli Atti (Italy); Irina Lucenko (Latvia); Grazina Rimseliene, Snieguole Dauksiene (Lithuania); Pierette Huberty-Krau, Francois Schneider (Luxembourg); Jackie Maistre Melillo (Malta); Sabine de Greeff, Hester de Melker, Lodewijk Spanjaard (Netherlands); Hans Blystad, E. Arne Hoiby, Øistein Løvoll (Norway); Andrzej Zielinski, Waleria Hryniewicz, Anna Skoczynska, Marcin Kadlubowski (Poland); Laurinda Queirós, Paula Lavado (Portugal); Claire Cameron, Barbara Denham, Fiona Johnston (Scotland); Margareta Slacikova, Elena Novakova (Slovak Republic); Alenka Kraigher, Metka Paragi (Slovenia); Jose Campos, Javier Diez-Domingo (Spain); Rose-Marie Carlsson, Birgitta Henriques Normark (Sweden); Hans-Peter Zimmermann (Switzerland).