Volume 11, Number 2—February 2005
Research
Pneumocystis jirovecii in General Population
Francisco J. Medrano*
, Marco Montes-Cano*, Manuel Conde*, Carmen de la Horra*, Nieves Respaldiza*, Antonia Gasch*, Maria J. Perez-Lozano*, Jose M. Varela*, and Enrique J. Calderon*
, Marco Montes-Cano*, Manuel Conde*, Carmen de la Horra*, Nieves Respaldiza*, Antonia Gasch*, Maria J. Perez-Lozano*, Jose M. Varela*, and Enrique J. Calderon*
Table
Epidemiologic, biologic, and microbiologic features of healthy Pneumocystis carriers*
| Participant (age [y], sex)† | Profession | Alcohol intake >40 g/day | Smoking habit | Total lymphocyte count (cells/μL) | CD4+ cell count (cells/μL) | mtLSU-rRNA genotype (nucleotide position: identity) | DHPS genotype (codon position: identity) by PCR-RFLP assay | PCR result at month 6 of follow-up |
|---|---|---|---|---|---|---|---|---|
| 1 (28, F) | Administrative | No | No | 2,327 | 653 | 3 (85:T/248:C) | 1 (55:Thr/57:Pro) | + |
| 2 (42, F) | Administrative | No | No | 2,455 | 1,168 | 1 (85:C/248:C) | 1 (55:Thr/57:Pro) | – |
| 3 (43, F) | Administrative | No | No | NA | NA | 4 (85:C/248:T) | Not amplified | – |
| 4 (40, M) | Administrative | Yes | No | 1,528 | 520 | 3 (85:T/248:C) | Not amplified | – |
| 5 (41, F) | New resident | No | No | NA | NA | 2 (85:A/248:C) | 1 (55:Thr/57:Pro) | NA |
| 6 (27, F) | New resident | No | No | 1,354 | 550 | 2 (85:A/248:C) | 1 (55:Thr/57:Pro) | – |
| 7 (32, F) | New resident | No | No | 2,300 | 604 | 1 (85:C/248:C) | 1 (55:Thr/57:Pro) | – |
| 8 (40, M) | University staff | Yes | Yes | 1,730 | 924 | 2 (85:A/248:C) | 1 (55:Thr/57:Pro) | + |
| 9 (26, M) | University staff | Yes | Yes | 3,602 | 924 | 2 (85:A/248:C) | 1 (55:Thr/57:Pro) | – |
| 10 (42, M) | University staff | No | No | 1,518 | 432 | 1 (85:C/248:C) | Not amplified | – |
*mtLSU-rRNA, mitochondrial large subunit ribosomal RNA; DHPS, dihydropteroate synthase; PCR, polymerase chain reaction; RFLP, restriction fragment length polymorphism; F, female; M, male; +, positive result; –, negative result; NA, not available.
†Chest radiograph results were normal for all participants, except participant 5, for whom results were not available, and participant 9, who showed an apical cystic bullae.
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