Volume 13, Number 3—March 2007
Research
Worldwide Emergence of Extensively Drug-resistant Tuberculosis
Table 1
Pattern | Other 13 SRLs (n = 5,751) | Republic of Korea SRL (n = 11,939) | ||
---|---|---|---|---|
No. tested | No. (%) resistant | No. tested | No. (%) resistant | |
Any resistance (total)*†‡ | 5,751 | 3,765 (65.5) | 11,939 | 2,508 (21.0) |
INH | 5,645 | 3,305 (58.5) | 11,939 | 2,196 (18.4) |
RIF | 5,649 | 2,345 (41.5) | 11,939 | 1,469 (12.3) |
EMB | 5,508 | 1,356 (24.6) | 11,939 | 988 (8.3) |
SM | 5,618 | 2,581 (45.9) | 11,939 | 578 (4.8) |
Monoresistance (total)§¶ | 5,751 | 884 (15.4) | 11,939 | 952 (8.0) |
INH | 5,645 | 456 (8.1) | 11,939 | 666 (5.6) |
RIF | 5,649 | 99 (1.8) | 11,939 | 148 (1.2) |
EMB | 5,508 | 8 (0.1) | 11,939 | 25 (0.2) |
SM | 5,618 | 321 (5.7) | 11,939 | 113 (0.9) |
Polyresistance, non-MDR (total)¶ | 5,644 | 651 (11.5) | 11,939 | 258 (2.2) |
INH + other drugs (except RIF) | 5,645 | 627 (11.1) | 11,939 | 232 (1.9) |
RIF + other drugs (except INH) | 5,649 | 24 (0.4) | 11,939 | 23 (0.2) |
Multidrug resistance (total)¶# | 5,644 | 2,222 (39.4) | 11,939 | 1,298 (10.9) |
INH + RIF, only | 5,644** | 399 (7.1) | 11,939 | 392(3.3) |
INH + RIF + EMB, only | 5,508** | 182 (3.3) | 11,939 | 584 (4.9) |
INH + RIF + SM, only | 5,618** | 619 (11.0) | 11,939 | 89 (0.7) |
INH + RIF + EMB + SM | 5,476** | 1,017 (18.6) | 11,939 | 233 (2.0) |
*SRLs, Supranational Reference Laboratories; INH, isoniazid; RIF, rifampin; EMB, ethambutol; SM, streptomycin.
†Missing data for INH (106 isolates), RIF (102 isolates), EMB (243 isolates), SM (133 isolates).
‡Cells are not mutually exclusive.
§Numerator is isolates with resistance to the specified drug and no known resistance to other first-line drugs. Denominator is isolates tested to at least the specified drug in the numerator.
¶Each cell is mutually exclusive.
#Denominator is isolates tested for at least INH + RIF.
**Denominator is isolates tested for at least the drugs in the specified combination.
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