Volume 14, Number 8—August 2008
CME ACTIVITY - Research
Systematic Literature Review of Role of Noroviruses in Sporadic Gastroenteritis
Manish M. Patel*
, Marc-Alain Widdowson*, Roger I. Glass*†, Kenichiro Akazawa‡, Jan Vinjé*, and Umesh D. Parashar*
, Marc-Alain Widdowson*, Roger I. Glass*†, Kenichiro Akazawa‡, Jan Vinjé*, and Umesh D. Parashar*
Table 3
Estimates of annual number of episodes of norovirus-associated diarrhea among children <5 years of age in industrialized and developing countries, by setting
| Setting | Annual no. diarrhea-associated events* | Pooled proportion of episodes attributable to noroviruses, % | Total no. norovirus episodes | Annual incidence per 100,000 children†‡ |
|---|---|---|---|---|
| Industrialized countries† | ||||
| Outpatient | 7,743,000 | 11.7 | 906,000 | 1,665 |
| Inpatient | 531,000 | 12.1 | 64,200 | 118 |
| Developing countriesठ| ||||
| Inpatient | 9,015,000 | 12.1 | 1,091,000 | 197 |
| Deaths | 1,800,000 | 12.1 | 218,000 | 39 |
*Refer to Methods section of article.
†Industrialized countries’ incidence based on UNICEF 2003 population estimates of 54,425,000 children <5 y of age in developing countries (www.unicef.org/sowc05/english/Developingregional.html).
‡Developing countries’ incidence based on UNICEF 2003 population estimates of 552,742,000 children <5 y of age in industrialized (www.unicef.org/sowc05/english/Industrializedregional.html)
§Data from developing countries were sparse on fraction of norovirus-associated diarrhea episodes in the outpatient setting.
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