Volume 16, Number 10—October 2010
CME ACTIVITY - Research
Bloodstream Infections among HIV-Infected Outpatients, Southeast Asia
Jay K. Varma
, Kimberly D. McCarthy, Theerawit Tasaneeyapan, Patama Monkongdee, Michael E. Kimerling, Eng Buntheoun, Delphine Sculier, Chantary Keo, Praphan Phanuphak, Nipat Teeratakulpisarn, Nibondh Udomsantisuk, Nguyen H. Dung, Nguyen T.N. Lan, Nguyen T.B. Yen, and Kevin P. Cain
, Kimberly D. McCarthy, Theerawit Tasaneeyapan, Patama Monkongdee, Michael E. Kimerling, Eng Buntheoun, Delphine Sculier, Chantary Keo, Praphan Phanuphak, Nipat Teeratakulpisarn, Nibondh Udomsantisuk, Nguyen H. Dung, Nguyen T.N. Lan, Nguyen T.B. Yen, and Kevin P. Cain
Table 2
Multivariate analysis of risk factors for clinically significant BSI caused by mycobacterial or other bacterial infection in HIV-infected outpatients, Thailand, Cambodia, and Vietnam, September 2006–July 2008*
| Characteristic | Adjusted odds ratio (95% CI) for BSI |
||
|---|---|---|---|
| Any pathogen† | Mycobacteria‡ | Bacteria§ | |
| CD4 cell count <100/mm3 | 5.8 (2.5–13.7) | 11.2 (3.0–41.3) | – |
| Female sex | 0.4 (0.2–0.9) | – | – |
| Fever in past 24 h | – | – | 4.7 (1.2–17.6) |
| Loss of appetite in past 24 h | 2.0 (1.0–3.9) | – | – |
| Nausea or vomiting in past 24 h | 2.5 (1.2–5.0) | – | – |
| Shaking chills in past 24 h | – | 3.1 (1.1–9.1) | – |
| Difficulty breathing | – | 4.1 (1.5–11.1) | – |
| Diarrhea in past 24 h | – | 4.2 (1.6–11.3) | – |
| Jaundice | – | – | 12.5 (1.4–112.3) |
| Ever injected drug | – | – | – |
| Temperature >38°C | 3.2 (1.6–6.3) | 5.7 (2.1–15.4) | – |
| Heart rate >100 bpm | – | – | – |
| Oral hairy leukoplakia | 2.8 (1.4–5.7) | – | – |
| Hemoglobin level <12 g/dL | 4.8 (2.0–11.7) | – | – |
| Leukocyte count >12 × 103/µL | 3.7 (1.4–9.3) | 15.3 (4.9–48.2) | – |
| Thrombocyte count <100,000 cells/µL | – | 7.0 (1.8–27.6) | – |
| Paratracheal adenopathy on chest radiograph | 5.0 (2.1–11.6) | 11.3 (3.7–34.3) | – |
| Miliary pattern on chest radiograph | 6.0 (1.8–19.5) | 14.2 (3.4–58.6) | – |
| Took antimicrobial medication other than cotrimoxazole | – | 5.1 (1.6–16.8) | – |
*BSI, bloodstream infection; CI, confidence interval; bpm, beats per minute; –, variable was not included in the model.
†1,961 patients in final model.
‡1,944 patients in final model.
§1,961 patients in final model.
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