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Volume 19, Number 12—December 2013
CME ACTIVITY - Synopsis

Potential Role of Deer Tick Virus in Powassan Encephalitis Cases in Lyme Disease–endemic Areas of New York, USA

Marc Y. El Khoury1Comments to Author , Jose F. Camargo1, Jennifer L. White, Bryon P. Backenson, Alan P. Dupuis, Kay L. Escuyer, Laura Kramer, Kirsten St. George, Debarati Chatterjee, Melissa Prusinski, Gary P. Wormser, and Susan J. Wong
Author affiliations: New York Medical College, Valhalla, NY, USA (M.Y. El Khoury, J.F. Camargo, D. Chatterjee, G.P. Wormser); Wadsworth Center, New York State Department of Health, Albany, NY, USA (J.L. White, B.P. Backenson, A.P. Dupuis II, K.L. Escuyer, L. Kramer, K. St. George, M. Prusinski, S.J. Wong)

Main Article

Table 3

Diagnostic evaluation and outcome of POWV/DTV encephalitis, by county and date of illness, New York, USA, 2004–2012*

Category Data by case no.
1 2 3 4 5 6 7 8 9 10 11 12 13† 14
Patient age, y 91 83 70 5 62 77 81 81 9 4 76 73 77 32
Date of illness Jun 2004 Aug 2005 Jun 2007 Aug 2007 Jun 2007 Nov 2007 Nov 2007 Jul 2007 Jul 2008 Apr 2009 Jan 2009 Jun 2009 Dec 2010 Apr 2012
County Alb West Cort Lewis Put West West West West Dutch Mad Put Put Dutch
LHV
No
Yes
No
No
Yes
Yes
Yes
Yes
Yes
Yes
No
Yes
Yes
Yes
POWV MIA
Acute Pos Neg Pos Pos ND Pos Pos Neg Pos Pos Neg Pos Pos Pos
Conv
Pos
Pos
Pos
Pos
ND
Pos
Pos
Ind
Pos
Pos
Pos
Pos
Pos
Pos
PRNT titer
Acute 40,960 320 320 20 ND 320 1,280 <10 10 320 <10 2,560 5,120 1,280
Conv
40,960
1,280
320
80
ND
320
5,120
40
160
2,560
40
20,480
5,120
320
PCR for POWV/DTV NS5 gene
ND
ND
ND
ND
Pos (brain)
ND
ND
Neg
ND
Neg
Neg
Neg
Pos (CSF)
Neg
Lineage U U U U DTV U U U U U U U DTV U
Outcome
LADL
LADL
Died
LADL
Died
Died
LADL
Died
LADL‡
LADL
LADL
LADL‡
Died
LADL
WNV testing
ELISA IgM–, IgG+ Neg Neg IgM–, IgG+ ND Neg Neg Neg Neg Neg Neg Neg Neg Neg
PRNT
Neg
Neg
NA
Neg
NA
Neg
NA
NA
NA
Neg
NA
NA
Neg
Neg
SLEV PRNT
Acute Neg 10 Neg NA NA Neg NA NA NA Neg NA NA Neg Neg
Conv Neg 80 Neg NA NA Neg NA NA NA Neg NA NA Neg Neg
[[tablefoot]]

Main Article

1These authors contributed equally to this article.

Page created: December 11, 2013
Page updated: December 11, 2013
Page reviewed: December 11, 2013
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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