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Volume 20, Number 11—November 2014
Research

Drug-Resistant Candida glabrata Infection in Cancer Patients

Dimitrios Farmakiotis1, Jeffrey J. Tarrand, and Dimitrios P. KontoyiannisComments to Author 
Author affiliations: The University of Texas MD Anderson Cancer Center, Houston, Texas, USA (D. Farmakiotis, J.J. Tarrand, D.P. Kontoyiannis); Baylor College of Medicine, Houston (D. Farmakiotis)

Main Article

Table 3

Factors present at the time of candidemia and associated with caspofungin resistance in cancer patients with Candida glabrata fungemia, MD Anderson Cancer Center, Houston, Texas, USA, March 2005–September 2013*

Factor No. (%)
 p value Multivariate analysis
Susceptible
(n = 107) Intermediate
 (n = 24) Resistant
(n = 15) Odds ratio (95% CI) p value
Hematologic malignancy 27 (25.23) 12 (50) 8 (53.33) .012
Leukemia 12 (11.21) 4 (16.66) 6 (40) .012
Hematopoetic stem cell transplantation 6 (5.61) 5 (20.83) 5 (33.33) .013
Neutropenia (<500 cells/μL) 16 (14.95) 6 (25) 6 (40) .016
Lymphopenia (<500 cells/μL) 59 (55.14) 15 (62.5) 12 (80) .069
Monocytopenia (<100 cells/μL) 20 (18.69) 10 (41.66) 9 (60) <0.001 3.53 (1.44–8.65) .006
Mechanical ventilation 17 (15.89) 3 (12.5) 7 (46.66) .024
Any corticosteroids† 56 (52.33) 17 (70.83) 12 (80) .004
Total parenteral nutrition 22 (20.56) 5 (20.83) 9 (60) .005 3.37 (1.37–8.24) .008
Echinocandin exposure† 15 (14.02) 6 (25) 11 (73.33) <0.001 2.75 (1.09–6.95) .032
Fluconazole resistance 15 (14.02) 6 (25) 9 (60) <0.001 3.16 (1.13–7.88) .013

Main Article

1Current affiliation: Harvard Medical School Brigham and Women’s Hospital and Dana Farber Cancer Institute, Boston, Massachusetts, USA

Page created: October 15, 2014
Page updated: October 15, 2014
Page reviewed: October 15, 2014
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