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Volume 21, Number 1—January 2015
Research

Neurotropic Threat Characterization of Burkholderia pseudomallei Strains

Jodie L. MorrisComments to Author , Anne Fane, Catherine M. Rush, Brenda L. Govan, Mark Mayo, Bart J. Currie, and Natkunam Ketheesan
Author affiliations: James Cook University, Townsville, Queensland, Australia (J. Morris, A. Fane, C. Rush, B. Govan, N. Ketheesan); Menzies School of Health Research, Darwin, Northern Territory, Australia (M. Mayo, B.J. Currie); Royal Darwin Hospital, Darwin (B.J. Currie)

Main Article

Table 2

Development of signs of neurologic involvement* in C57BL/6 mice after intranasal infection with Burkholderia pseudomallei strains isolated from patients with neurologic and non-neurologic melioidosis, Northern Territory, Australia, October 1989–October 2012

MSHR ID no.† Inoculating dose, CFU No. mice with neurologic signs/total mice infected
Neurologic
668
 2.9 × 103
 1/5
2.9 × 104
 0/5
2.9 × 105
 2/5
2.9 × 106
 2/5
305
 2.6 × 103
 0/5
2.6 × 104
 1/5
2.6 × 105
 3/5
2.6 × 106
 0/5
62
 2.2 × 103
 1/5
2.2 × 104
 1/5
2.2 × 105
 2/5
2.2 × 106
 1/5
435
 3.0 × 103
 0/5
3.0 × 104
 3/5
3.0 × 105
 2/5
3.0 × 106
 2/5
1153
 5.3 × 101
 1/5
5.3 × 102
 3/5
5.3 × 103
 0/5
5.3 × 104
 1/5
3709
 2.2 × 103
 0/5
2.2 × 104
 0/5
2.2 × 105
 0/5
2.2 × 106
 0/5
Non-neurologic
1655
 1.1 × 104
 0/5
1.1 × 105
 0/5
1.1 × 106
 0/5
1.1 × 107
 0/5
465
 6.6 × 103
 0/5
6.6 × 104
 0/5
6.6 × 105
 2/6
6.6 × 106
 1/6
2138
 2.4 × 102
 0/5
2.4 × 103
 0/5
2.4 × 104
 1/5
2.4 × 105
 2/4
346
 4.2 × 103
 0/5
4.2 × 104
 0/5
4.2 × 105
 2/5
4.2 × 106
 0/5
543
 9.4 × 102
 1/5
9.4 × 103
 1/5
9.4 × 104
 3/5
9.4 × 105 2/5

*Head tilt, difficulty walking, limb paresis.
†MSHR ID, neurologic isolate identification.

Main Article

Page created: December 17, 2014
Page updated: December 17, 2014
Page reviewed: December 17, 2014
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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