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Volume 21, Number 1—January 2015
CME ACTIVITY - Research

Clinical Course and Long-Term Outcome of Hantavirus-Associated Nephropathia Epidemica, Germany

Joerg Latus, Matthias Schwab, Evelina Tacconelli, Friedrich-Michael Pieper, Daniel Wegener, Juergen Dippon, Simon Müller, David Zakim, Stephan Segerer, Daniel Kitterer, Martin Priwitzer, Barbara Mezger, Birgit Walter-Frank, Angela Corea, Albrecht Wiedenmann, Stefan Brockmann, Christoph Pöhlmann, M. Dominik Alscher, and Niko BraunComments to Author 
Author affiliations: Robert-Bosch-Hospital, Stuttgart, Germany (J. Latus, F.-M. Pieper, D. Wegener, D. Zakim, D. Kitterer, C. Pöhlmann, M.D. Alscher, N. Braun); Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart (M. Schwab); University Hospital Tübingen, Germany (M. Schwab, E. Tacconelli); University of Stuttgart, Stuttgart (J. Dippon, S. Müller); University Hospital Zurich, Zurich, Switzerland (S. Segerer); Local Health Authority, Stuttgart (M. Priwitzer, B. Mezger); Local Health Authority, Böblingen, Germany (B. Walter-Frank); Local Health Authority, Esslingen, Germany (A. Corea, A. Wiedenmann); Local Health Authority, Reutlingen, Germany (S. Brockmann)

Main Article

Table 2

Laboratory results for serum samples obtained from 456 persons experiencing acute hantavirus-associated nephropathia epidemica, Germany, 2001–2012*

Laboratory test Median value (range) Reference value
Creatinine, serum, maximum
 2.7 mg/dL (1.6–4.8)
 0.5–1.4 mg/dL
Platelet count >150 × 109/L
At admission or first visit with a general practitioner/nephrologist 122 (81–197)
Minimum 113 (75–189)
At discharge§
 281 (226–353)
Hematocrit 0.37–0.47
At admission or first visit with a general practitioner/nephrologist 0.42 (0.39–0.47)
At discharge
 0.40 (0.36–0.43)
C-reactive protein 0.1–0.4 mg/dL
At admission or first visit with a general practitioner/nephrologist 4 mg/dL (2.4–7.1)
Maximum 4.5 mg/dL (2.8–8.2)
At discharge§
 0.9 mg/dL (0.4–1.7)
Liver enzyme†
Aspartate aminotransferase <50 U/L
At admission or first visit with a general practitioner/nephrologist 36 U/L (27–55)
At discharge§ 51 U/L (30–71)
Alanine aminotransferase <50 U/L
At admission or first visit with a general practitioner/nephrologist 35 U/L (24–57)
At discharge§
 64 U/L (35–101)
Lactate dehydrogenase‡ 273 U/L (240–323) <250 U/L

*All patients were adults who had received a diagnosis of serologically and clinically confirmed hantavirus infection.
†35% of patients had elevated levels of liver enzymes at admission or first visit with a general practitioner/nephrologist.
‡66% of patients had elevated levels of lactate dehydrogenase at admission or first visit with a general practitioner/nephrologist.
§335 patients who received in-patient treatment.

Main Article

Page created: December 17, 2014
Page updated: December 17, 2014
Page reviewed: December 17, 2014
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