Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 21, Number 11—November 2015
Dispatch

Middle East Respiratory Syndrome in 3 Persons, South Korea, 2015

Jeong-Sun Yang, SungHan Park, You-Jin Kim, Hae Ji Kang, Hak Kim, Young Woo Han, Han Saem Lee, Dae-Won Kim, A-Reum Kim, Deok Rim Heo, Joo Ae Kim, Su Jin Kim, Jeong-Gu Nam, Hee-Dong Jung, Hyang-Min Cheong, Kisoon Kim, Joo-Shil Lee, and Sung Soon KimComments to Author 
Author affiliations: Korea Centers for Disease Control and Prevention, Cheongju, South Korea

Main Article

Figure 2

Phylogenetic tree comparing complete genome nucleotide sequences of Middle East respiratory syndrome coronavirus (MERS-CoV) isolate from South Korea (KOR/KNIH/002_05_2015) with those of 67 reference MERS-CoVs (GenBank database). The tree was constructed by using the general time reversible plus gamma model of RAxML version 8.8.0 software (10) and visualized by using FigTree version 1.4.2 (http://tree.bio.ed.ac.uk/software/figtree). RAxML bootstrap values (1,000 replicates) are shown above the br

Figure 2. Phylogenetic tree comparing complete genome nucleotide sequences of Middle East respiratory syndrome coronavirus (MERS-CoV) isolate from South Korea (KOR/KNIH/002_05_2015) with those of 67 reference MERS-CoVs (GenBank database). The tree was constructed by using the general time reversible plus gamma model of RAxML version 8.8.0 software (10) and visualized by using FigTree version 1.4.2 (http://tree.bio.ed.ac.uk/software/figtree). RAxML bootstrap values (1,000 replicates) are shown above the branches. Bootstrap values >75 are shown on the branches. The MERS-CoV strain from South Korea is shown in gray. National Center for Biotechnology Information accession numbers are shown before each taxon name. The unit of branch length is the number of substitutions per site. Scale bar indicates 4 × 10–4 nucleotide substitutions per site.

Main Article

References
  1. Zaki  AM, van Boheemen  S, Bestebroer  TM, Osterhaus  AD, Frouchier  RA. Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. N Engl J Med. 2012;367:1814–20 . DOIPubMedGoogle Scholar
  2. World Health Organization. Emergencies preparedness, response: Middle East respiratory syndrome coronavirus (MERS-CoV) maps and epicurves. 10–16 August 2015 [cited 2015 Aug 20]. http://www.who.int/csr/disease/coronavirus_infections/maps-epicurves/en
  3. Korea Society of Infectious Diseases, Korean Society for Healthcare-associated Infection Control and Prevention. An unexpected outbreak of Middle East respiratory syndrome coronavirus infection in the Republic of Korea, 2015. Infect Chemother. 2015;47:120–2.
  4. Cowling  BJ, Park  M, Fang  VJ, Wu  P, Leung  GM, Wu  JT. Preliminary epidemiological assessment of MERS-CoV outbreak in South Korea, May to June 2015. Euro Surveill. 2015;20:21163 .PubMedGoogle Scholar
  5. Lee  SS, Wong  NS. Probable transmission chains of Middle East respiratory syndrome coronavirus and the multiple generations of secondary infection in South Korea. Int J Infect Dis. 2015;38:65–7 . DOIPubMedGoogle Scholar
  6. Korea Centers for Disease Control and Prevention. MERS countermeasure guideline (revised December 2014) [in Korean]. Cheongju (South Korea): The Centers; 2014.
  7. World Health Organization. Laboratory testing for Middle East respiratory syndrome coronavirus. Interim recommendations (revised). September 2014. Geneva: The Organization; 2014.
  8. Corman  VM, Eckerle  I, Bleicker  T, Zaki  A, Landt  O, Eschbach-Bludau  M, Detection of a novel human coronavirus by real-time reverse-transcription polymerase chain reaction. Euro Surveill. 2012;17:20285 .PubMedGoogle Scholar
  9. Corman  VM, Muller  MA, Costabel  U, Timm  J, Binger  T, Meyer  B, Assays for laboratory confirmation of novel human coronavirus (hCoV-EMC) infections. Euro Surveill. 2012;17:pii20334 .PubMedGoogle Scholar
  10. Stamatakis  A. RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies. Bioinformatics. 2014;30:1312–3. DOIPubMedGoogle Scholar
  11. Spanakis  N, Tsiodras  S, Haagmans  BL, Raj  VS, Pontikis  K, Koutsoukou  A, Virological and serological analysis of a recent Middle East respiratory syndrome coronavirus infection case on a triple combination antiviral regimen. Int J Antimicrob Agents. 2014;44:528–32. DOIPubMedGoogle Scholar
  12. Drosten  C, Seilmaier  M, Corman  VM, Hartmann  W, Scheible  G, Sack  S, Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection. Lancet Infect Dis. 2013;13:745–51. DOIPubMedGoogle Scholar
  13. Poissy  J, Goffard  A, Parmentier-Decrucq  E, Favory  R, Kauv  M, Kipnis  E, Kinetics and pattern of viral excretion in biological specimens of two MERS-CoV cases. J Clin Virol. 2014;61:275–8. DOIPubMedGoogle Scholar

Main Article

Page created: October 19, 2015
Page updated: October 19, 2015
Page reviewed: October 19, 2015
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external