Volume 21, Number 3—March 2015
Research
Risk Factors for Death from Invasive Pneumococcal Disease, Europe, 2010
Adoración Navarro-Torné
, Joana Gomes Dias, Frantiska Hruba, Pier Luigi Lopalco, Lucia Pastore-Celentano, Andrew J. Amato Gauci, and Invasive Pneumococcal Disease Study Group
, Joana Gomes Dias, Frantiska Hruba, Pier Luigi Lopalco, Lucia Pastore-Celentano, Andrew J. Amato Gauci, and Invasive Pneumococcal Disease Study Group
Table 3
Streptococcus pneumoniae serotype in invasive pneumococcal disease and association with death, Europe, 2010*
| Serotype | PCV† | Fatal, % | Nonfatal, % | RR (95% CI) | p value‡ |
|---|---|---|---|---|---|
| 3 | PCV13-specific§ | 13.3 | 9.6 | 1.39 (0.88–2.21) | 0.161 |
| 4 | PCV7 | 6.1 | 2.8 | 2.03 (1.04–3.95) | 0.038 |
| 19A | PCV13-specific | 6.1 | 7.6 | 0.80 (0.41–1.57) | 0.515 |
| 14 | PCV7 | 5.7 | 4.6 | 1.23 (0.78–1.85) | 0.369 |
| 7F | PCV13-specific | 4.9 | 8.3 | 0.59 (0.35–1.01) | 0.053 |
| 6B | PCV7 | 3.8 | 1.7 | 2.01 (0.79–5.16) | 0.144 |
| 19F | PCV7 | 3.8 | 1.9 | 1.85 (0.93–3.65) | 0.078 |
| 22F | Non-PCV | 3.8 | 2.8 | 1.35 (0.89–2.03) | 0.157 |
| 9V | PCV7 | 3.4 | 2.2 | 1.50 (0.95–2.38) | 0.081 |
| 23F | PCV7 | 3.4 | 2.3 | 1.42 (0.60–3.32) | 0.423 |
| 1 | PCV13-specific | 3.4 | 13.1 | 0.25 (0.13–0.48) | <0.001 |
| 11A | Non-PCV | 2.3 | 1.1 | 1.97 (1.33–2.94) | 0.001 |
| 10A | Non-PCV | 2.3 | 1.4 | 1.52 (0.86–2.68) | 0.147 |
| 6A | PCV13-specific | 2.3 | 2.3 | 1.01 (0.39–2.57) | 0.990 |
| 6C | Non-PCV | 1.9 | 0.7 | 2.33 (0.93–5.86) | 0.072 |
| 9N | Non-PCV | 1.9 | 1.5 | 1.21 (0.52–2.82) | 0.664 |
| 12F | Non-PCV | 1.9 | 1.8 | 1.07 (0.51–2.23) | 0.867 |
| 35B | Non-PCV | 1.5 | 0.2 | 4.98 (2.49–9.95) | <0.001 |
| 33F | Non-PCV | 1.5 | 0.9 | 1.53 (0.55–4.28) | 0.414 |
| 18C | PCV7 | 1.5 | 1.2 | 1.23 (0.40–3.76) | 0.713 |
| 8 | Non-PCV | 1.5 | 3.1 | 0.59 (0.25–1.06) | 0.073 |
| 23A | Non-PCV | 1.1 | 0.7 | 1.51 (0.66–3.45) | 0.323 |
| 15A | Non-PCV | 0.8 | 0.7 | 1.05 (0.46–2.43) | 0.909 |
| 15B | Non-PCV | 0.8 | 1.0 | 0.79 (0.26–2.41) | 0.677 |
| 24F | Non-PCV | 0.4 | 0.6 | 0.69 (0.12–4.09) | 0.683 |
| 5 | PCV13-specific | 0.4 | 2.6 | 0.15 (0.09–0.26) | <0.001 |
*PCV, pneumococcal conjugate vaccine; PCV7, 7-valent PCV; PCV13, 13-valent PCV; RR, relative risk. Boldface indicates statistical significance.
†Classification of serotypes according to study group.
‡Generalized linear model with log-link function.
§Serotypes contained in PCV13 but not in PCV7.
1Members of the Invasive Pneumococcal Disease Study Group who contributed data are listed at the end of this article.
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