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Volume 21, Number 9—September 2015
THEME ISSUE
Emerging Infections Program
Emerging Infections Program

Improving Accuracy of Influenza-Associated Hospitalization Rate Estimates

Alexander J. MillmanComments to Author , Carrie Reed, Pam Daily Kirley, Deborah Aragon, James I. Meek, Monica M. Farley, Patricia Ryan, Jim Collins, Ruth Lynfield, Joan Baumbach, Shelley Zansky, Nancy M. Bennett, Brian Fowler, Ann Thomas, Mary L. Lindegren, Annette Atkinson, Lyn Finelli, and Sandra Chaves
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (A.J. Millman, C. Reed, L. Finelli, S.S. Chaves); California Emerging Infections Program, Oakland, California, USA (P. Daily Kirley); Colorado Department of Public Health and Environment, Denver, Colorado, USA (D. Aragon); Connecticut Emerging Infections Program, New Haven, Connecticut, USA (J. Meek); Emory University School of Medicine, Atlanta (M.M. Farley); Atlanta Veterans Administration Medical Center, Atlanta (M.M. Farley); Maryland Department of Health and Mental Hygiene, Baltimore, Maryland, USA (P. Ryan); Michigan Department of Health and Human Services, Lansing, Michigan, USA (J. Collins); Minnesota Department of Health, St. Paul, Minnesota, USA (R. Lynfield); New Mexico Department of Health, Santa Fe, New Mexico, USA (J. Baumbach); New York State Department of Health, Albany, New York, USA (S. Zansky); University of Rochester School of Medicine and Dentistry, Rochester, New York, USA (N.M. Bennett); Monroe County Department of Public Health, Rochester (N.M. Bennett); Ohio Department of Health, Columbus, Ohio, USA (B. Fowler); Oregon Public Health Division, Portland, Oregon, USA (A. Thomas); Vanderbilt University School of Medicine, Nashville, Tennessee, USA (M.L. Lindegren); Utah Department of Health, Salt Lake City, Utah, USA (A. Atkinson)

Main Article

Table

Influenza diagnostic test sensitivity range, by patient age group (years), FluSurv-NET, 2003–2013*

Diagnostic test/patient age group, y Range from literature review, % References Bootstrap estimate (95% CI)
RT-PCR
0–17 79.2–100 (19,21–24) 95.0 (82–98.7)
18–64 79.2–100 (19,21–23) 94.1 (81.1–98.7)
>65 79.2–93 (19,21,25) 86.1 (79.6–92.7)
Culture
0–17 45–100 (4,19,24,26) 69.3 (48.3–95.9)
18–64 45–100 (4,19,26) 72.8 (47.2–96.3)
>65 19.4–53.8 (8,25) 36.2 (20.3–52.1)
DFA
0–17 45–90 (24,27–30) 70.9 (46.8–86.6)
18–64 53–84.2 (27,28) 68.0 (53.8–83.4)
>65 53–84.2 (27,28) 68.0 (53.8–83.4)
RIDT
0–17 61.6–71.7 (7) 66.7 (61.3–71.7)
18–64 47.7–59.8 (7) 53.9 (47.8–59.8)
>65 8–43 (8,17,25,31) 20.1 (8.8–41.4)

*DFA, direct fluorescent antibody; FluSurv-NET, Centers for Disease Control and Prevention Influenza Hospital Surveillance Network; RIDT, rapid influenza diagnostic test; RT-PCR, reverse transcription PCR.

Main Article

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