Whole-Genome Sequencing to Determine Origin of Multinational Outbreak of Sarocladium kiliense Bloodstream Infections
Kizee A. Etienne
, Chandler C. Roe, Rachel Smith, Snigdha Vallabhaneni, Carolina Duarte, Patricia Escandón, Elizabeth Castañeda, Beatriz L. Gómez, Catalina de Bedout, Luisa F. López, Valentina Salas, Luz Maria Hederra, Jorge Fernández, Paola Pidal, Juan Carlos Hormazabel, Fernando Otaíza-O’Ryan, Fredrik O. Vannberg, John Gillece, Darrin Lemmer, Elizabeth M. Driebe, David M. Engelthaler, and Anastasia P. Litvintseva
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (K.A. Etienne, R.M. Smith, S. Vallabhaneni, A.P. Litvintseva); Georgia Institute of Technology, Atlanta (K.A. Etienne, F.O. Vannberg); Translational Genomics Research Institute, Flagstaff, Arizona, USA (C.C. Roe, J. Gillece, D. Lemmer, E.M. Driebe, D.M. Engelthaler); Instituto Nacional de Salud, Bogota, Colombia (C. Duarte, P. Escandón, E. Castañeda); Universidad del Rosario, Bogota (B.L. Gómez); Corporación para Investigaciones Biológicas, Medellín, Colombia (B.L. Gómez, C. de Bedout, L.F. López); Instituto de Salud Publica de Chile, Santiago, Chile (V. Salas, L.M. Hederra, J. Fernández, P. Pidal, J.C. Hormazabel); Ministry of Health, Santiago (F. Otaíza-O’Ryan)
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Figure
Figure. Whole-genome single-nucleotide polymorphism (SNP) typing of Sarocladium kiliense strains, Chile and Colombia, 2013–2014. All patient (clinical) and drug (vial) isolates from these 2 countries differed by <5 SNPs, and >21,000 SNPs were identified for the control isolates (≈117,000 total SNPs, ≈73,000 parsimoniously informative SNPs). Scale bar indicates nucleotide substitutions per site.
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