Volume 22, Number 3—March 2016
Dispatch
Signs or Symptoms of Acute HIV Infection in a Cohort Undergoing Community-Based Screening
Martin Hoenigl
, Nella Green, Martha Camacho, Sara Gianella, Sanjay R. Mehta, Davey M. Smith, and Susan J. Little
, Nella Green, Martha Camacho, Sara Gianella, Sanjay R. Mehta, Davey M. Smith, and Susan J. Little
Table 2
Signs or symptoms occurring in 69 persons with AHI, San Diego, California, USA, 2007–2014*
| Characteristic |
Signs/symptoms |
p value |
Signs/symptoms |
p value |
|||
|---|---|---|---|---|---|---|---|
| Compatible with AHI† |
Resolved before NAT |
Ongoing at NAT |
Persons seeking medical attention |
Persons not seeking medical attention |
|||
| No. persons reporting symptoms | 69 | 16 | 41 | 10 | 22 | ||
| Duration of symptoms, d, median (IQR) | 8 (5–11) | 7 (4–8) | 11 (7–13) | <0.01 | 13 (10–17) | 10 (4–11) | 0.01 |
| No. (%) persons with typical AHI |
64 (93) |
15 (94) |
36 (86) |
NS |
10 (100) |
18 (82) |
NS |
| Signs or symptoms, no. (%) | |||||||
| Fever | 53 (77) | 11 (69) | 34 (83) | NS | 9 (90) | 16 (73) | NS |
| Myalgia | 48 (70) | 13 (81) | 28 (68) | NS | 8 (80) | 12 (55) | NS |
| Fatigue | 48 (70) | 13(81) | 29 (71) | NS | 9 (90) | 13 (59) | NS |
| Headache | 42 (61) | 10 (63) | 27 (66) | NS | 8 (80) | 11 (50) | NS |
| Night sweats | 38 (55) | 5 (31) | 26 (63) | 0.04 | 7 (70) | 9 (41) | NS |
| Pharyngitis | 34 (49) | 9 (56) | 17 (41) | NS | 4 (40) | 11 (50) | NS |
| GI symptoms‡ | 29 (42) | 3 (19) | 22 (54) | 0.02 | 5 (50) | 7 (32) | NS |
| Rash | 19 (28) | 6 (38) | 12 (29) | NS | 5 (50) | 5 (23) | NS |
| Weight loss§ | 15 (22) | 2 (13) | 12 (29) | NS | 6 (60) | 3 (14) | 0.01 |
| Arthralgia | 14 (20) | 3 (19) | 8 (20) | NS | 4 (40) | 1 (5) | 0.02 |
*AHI, acute HIV infection; GI, gastrointestinal; IQR, interquartile range; NAT, nucleic acid amplification testing; NS, not significant.
†Defined as having started <4 days before estimated date of infection or after the estimated date of infection.
‡General GI symptoms (e.g., nausea, vomiting, and diarrhea).
§Weight loss >2.5 kg.
Page created: February 18, 2016
Page updated: February 18, 2016
Page reviewed: February 18, 2016
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