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Volume 23, Number 9—September 2017
Dispatch

Similarities of Variant Creutzfeldt-Jakob Disease Strain in Mother and Son in Spain to UK Reference Case

Abigail B. DiackComments to Author , Aileen Boyle, Diane Ritchie, Chris Plinston, Dorothy Kisielewski, Jesús de Pedro-Cuesta, Alberto Rábano, Robert G. Will1, and Jean C. Manson1
Author affiliations: The Roslin Institute, Easter Bush, Scotland, UK (A.B. Diack, A. Boyle, C. Plinston, D. Kisielewski, J.C. Manson); University of Edinburgh, Edinburgh, Scotland, UK (D. Ritchie, R.G. Will); Carlos III Institute of Health, Madrid, Spain (J. de Pedro-Cuesta, A. Rábano)

Main Article

Figure 1

Comparison of vCJD incubation periods in wild-type mice from inoculation of brain tissue homogenates from 2 patients from Spain (son, patient 1; mother, patient 2) with vCJD and a reference patient from the United Kingdom. Results show similar incubation period ranking. Incubation periods were calculated in mice showing clinical and pathologic signs of transmissible spongiform encephalopathy disease. There was a single positive case in VM mice from patient 2. Data show mean incubation period ± S

Figure 1. Comparison of vCJD incubation periods in wild-type mice from inoculation of brain tissue homogenates from 2 patients from Spain (son, patient 1; mother, patient 2) with vCJD and a reference patient from the United Kingdom. Results show similar incubation period ranking. Incubation periods were calculated in mice showing clinical and pathologic signs of transmissible spongiform encephalopathy disease. There was a single positive case in VM mice from patient 2. Data show mean incubation period ± SEM. vCJD, variant Creutzfeldt-Jakob disease.

Main Article

1These senior authors contributed equally to this article.

Page created: August 17, 2017
Page updated: August 17, 2017
Page reviewed: August 17, 2017
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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