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Volume 24, Number 11—November 2018
Dispatch

Detection and Characterization of Human Pegivirus 2, Vietnam

Nguyen To Anh, Nguyen Thi Thu Hong, Le Nguyen Truc Nhu, Tran Tan Thanh, Catherine Anscombe, Le Ngoc Chau, Tran Thi Thanh Thanh, Chuen-Yen Lau, Direk Limmathurotsakul, Nguyen Van Vinh Chau, H. Rogier van Doorn, Xutao Deng, Motiur Rahman, Eric Delwart, Thuy Le, Guy Thwaites, Le Van TanComments to Author , and for the Southeast Asia Infectious Disease Clinical Research Network
Author affiliations: Oxford University, Ho Chi Minh City, Vietnam (N.T. Anh, N.T.T. Hong, L.N.T. Nhu, T.T. Thanh, C. Anscombe, L.N. Chau, T.T.T. Thanh, H.R. van Doorn, M. Rahman, T. Le, G. Thwaites, L.V. Tan); University of Oxford, Oxford, UK (C. Anscombe, D. Limmathurotsakul, H.R. van Doorn, G. Thwaites); National Institutes of Health, Bethesda, Maryland, USA (C.-Y. Lau); Mahidol Oxford Tropical Research Unit, Bangkok, Thailand (D. Limmathurotsakul); Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam (N.V.V. Chau); Blood Systems Research Institute, San Francisco, California, USA (X. Deng, E. Delwart); University of California, San Francisco (X. Deng, E. Delwart)

Main Article

Table 1

Samples and viral metagenomic datasets used in screening for human pegivirus, and screening results, Vietnam*

Infection No. persons Screening approach No. positive for HPgV-2 Enrollment period Setting
Hepatitis C virus and HIV co-infection
 79
 HPgV-2–specific PCR and reference-based mapping of obtained viral metagenomics data
 5
 2010–2013
 Hospital for Tropical Diseases, 
Ho Chi Minh City
HIV monoinfection
 78
 HPgV-2–specific PCR
 0
 2010–2013
 Hospital for Tropical Diseases, 
Ho Chi Minh City
None (healthy volunteers)
 80
 HPgV-2–specific PCR
 0
 2010–2013
 Hospital for Tropical Diseases, 
Ho Chi Minh City
Hepatitis A virus
 71
 HPgV-2–specific PCR
 0
 2012–2014
 Hospital for Tropical Diseases, 
Ho Chi Minh City
Hepatitis B virus
 103
 HPgV-2–specific PCR
 0
 2012–2016
 Hospital for Tropical Diseases, 
Ho Chi Minh City; Dong Thap General Hospital, Dong Thap; Khanh Hoa Provincial Hospital, Nha Trang; Dac Lac Provincial Hospital, Dac Lac; Hue National Hospital, Hue
Hepatitis C virus† 394 Reference-based mapping of obtained viral metagenomics data 0 2012–2016 Hospital for Tropical Diseases, 
Ho Chi Minh City; Dong Thap General Hospital, Dong Thap; Khanh Hoa Provincial Hospital, Nha Trang; Dac Lac Provincial Hospital, Dac Lac; Hue National Hospital, Hue

*HPgV-2, human pegivirus.
†Whole-genome sequences of hepatitis C virus were obtained using a viral metagenomics approach (7). The resulting metagenomics datasets were then subjected to a reference-based mapping approach to search for the presence of HPgV-2 sequences.

Main Article

1Members of the Southeast Asia Infectious Disease Clinical Research Network are listed at the end of this article.

Page created: October 17, 2018
Page updated: October 17, 2018
Page reviewed: October 17, 2018
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