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Volume 24, Number 3—March 2018
Synopsis

Multistate Epidemiology of Histoplasmosis, United States, 2011–20141

Paige A. ArmstrongComments to Author , Brendan R. Jackson, Dirk Haselow, Virgie Fields, Malia Ireland, Connie Austin, Kimberly Signs, Veronica Fialkowski, Reema Patel, Peggy Ellis, Peter C. Iwen, Caitlin Pedati, Suzanne Gibbons-Burgener, Jannifer Anderson, Thomas Dobbs, Sherri Davidson, Mary McIntyre, Kimberly Warren, Joanne Midla, Nhiem Luong, and Kaitlin Benedict
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (P.A. Armstrong, B.R. Jackson, C. Pedati, K. Benedict); Arkansas Department of Health, Little Rock, Arkansas, USA (D. Haselow, V. Fields, V. Fialkowski); Minnesota Department of Health, Saint Paul, Minnesota, USA (M. Ireland); Illinois Department of Public Health, Springfield, Illinois, USA (C. Austin); Michigan Department of Health and Human Services, Lansing, Michigan, USA (K. Signs, V. Fialkowski); Indiana State Department of Health, Indianapolis, Indiana, USA (R. Patel); Kentucky Department for Public Health, Frankfort, Kentucky, USA (P. Ellis); University of Nebraska Medical Center, Omaha, Nebraska, USA (P.C. Iwen); Nebraska Department of Health and Human Services, Lincoln, Nebraska, USA (C. Pedati); Wisconsin Department of Health Services, Madison, Wisconsin, USA (S. Gibbons-Burgener); Mississippi State Department of Health, Jackson, Mississippi, USA (J. Anderson, T. Dobbs); Alabama Department of Public Health, Montgomery, Alabama, USA (S. Davidson, M. McIntyre); Pennsylvania Department of Health, Harrisburg, Pennsylvania, USA (K. Warren); Ohio Department of Health, Columbus, Ohio, USA (J. Midla); Delaware Division of Public Health, Dover, Delaware, USA (N. Luong); 1This work was presented in part at the 2016 IDWeek Conference, the 66th Epidemic Intelligence Service Conference, and the 2017 Council of State and Territorial Epidemiologists Annual Conference.

Main Article

Table 3

Patient factors associated with hospitalization or death among histoplasmosis cases reported to public health, 12 US states, 2011–2014*

Characteristic
 Hospitalization
Death
RR (95% CI)
 p value
 RR (95% CI)
 p value
Age >50 y 1.23 (1.14–1.32) <0.001 6.28 (3.43–11.49) <0.001
Male sex 1.08 (1.01–1.45) 0.033 1.02 (0.65–1.58) 0.944
Nonwhite race† 1.26 (1.13–1.41) <0.001 0.82 (0.36–1.86) 0.627
Immunocompromised‡
 1.78 (1.62–1.96)
 <0.001
6.07 (2.61–14.11)
 <0.001
Positive laboratory test result§
Antigen 1.75 (1.62–1.89) 0.001 1.73 (1.04–2.87) 0.033
Antibody 0.58 (0.53–0.63) <0.001 0.41 (0.24–0.71) 0.001
Confirmatory 1.21 (1.09–1.34) 0.001 2.13 (1.28–3.54) 0.003

*RR, relative risk.
†Data collected by 8 states.
‡Data collected data by 3 states.
§Data collected by 9 states.

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Page created: February 15, 2018
Page updated: February 15, 2018
Page reviewed: February 15, 2018
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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