Volume 24, Number 4—April 2018
Etymologia
Etymologia: TEM
In 1965, the transferability of ampicillin resistance was reported, and the plasmid-encoded mechanism of resistance for 2 Salmonella sp. isolates from the United Kingdom and 1 Escherichia coli isolate from Greece was determined. Resistance (R) factors from Salmonella sp. isolates were designated R1818 and R7268 (R7268 encoding the current TEM-1). The E. coli isolate and its plasmid were named TEM (encoding the current TEM-2) because the isolate was recovered from a feces culture of an Athenian patient named Temoniera in 1963.
β-lactam resistance is a problem worldwide; >2,000 β-lactamases are currently identified. Of these β-lactamases, >200 enzymes are classified within TEM family, including extended-spectrum β-lactamases (ESBLs). However, the original TEM-1 and TEM-2 hydrolyze only penicillin derivatives.
References
- Ambler RP, Scott GK. Partial amino acid sequence of penicillinase coded by Escherichia coli plasmid R6K. Proc Natl Acad Sci U S A. 1978;75:3732–6. DOIPubMedGoogle Scholar
- Anderson ES, Datta N. Resistance to penicillins and its transfer in Enterobacteriaceae. Lancet. 1965;1:407–9. DOIPubMedGoogle Scholar
- Bonomo RA. β-lactamases: a focus on current challenges. Cold Spring Harb Perspect Med. 2017;7:a025239. DOIPubMedGoogle Scholar
- Bush K, Jacoby GA, Medeiros AA. A functional classification scheme for beta-lactamases and its correlation with molecular structure. Antimicrob Agents Chemother. 1995;39:1211–33. DOIPubMedGoogle Scholar
- Datta N, Kontomichalou P. Penicillinase synthesis controlled by infectious R factors in Enterobacteriaceae. Nature. 1965;208:239–41. DOIPubMedGoogle Scholar
- Kontomichalou P. Studies on resistance transfer factors. Pathol Microbiol (Basel). 1967;30:71–93.PubMedGoogle Scholar
- Sutcliffe JG. Nucleotide sequence of the ampicillin resistance gene of Escherichia coli plasmid pBR322. Proc Natl Acad Sci U S A. 1978;75:3737–41. DOIPubMedGoogle Scholar
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Table of Contents – Volume 24, Number 4—April 2018
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Joaquim Ruiz, PO Box 16, 08214 Badia del Valles, Spain
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