Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 24, Number 7—July 2018
CME ACTIVITY - Synopsis

Large Outbreaks of Fungal and Bacterial Bloodstream Infections in a Neonatal Unit, South Africa, 2012–2016

Erika van SchalkwykComments to Author , Samantha Iyaloo, Serisha D. Naicker, Tsidiso G. Maphanga, Ruth S. Mpembe, Thokozile G. Zulu, Mabatho Mhlanga, Sibongile Mahlangu, Motlatji B. Maloba, Grace Ntlemo, Kgomotso Sanyane, Dini Mawela, and Nelesh P. Govender
Author affiliations: University of Pretoria, Pretoria, South Africa (E. van Schalkwyk); National Institute for Communicable Diseases, Johannesburg, South Africa (E. van Schalkwyk, S. Iyaloo, S.D. Naicker, T.G. Maphanga, R.S. Mpembe, T.G. Zulu, M. Mhlanga, N.P. Govender); National Health Laboratory Service, Johannesburg (S. Mahlangu, M.B. Maloba, G. Ntlemo); Sefako Makgato Health Sciences University, Pretoria (S. Mahlangu, M.B. Maloba, G. Ntlemo, K. Sanyane, D. Mawela); University of the Witwatersrand, Johannesburg, (N.P. Govender); University of Cape Town, Cape Town, South Africa (N.P. Govender)

Main Article

Table 1

Characteristics of a cohort of 589 neonates, with and without Candida krusei candidemia, admitted to the neonatal unit at hospital A, Gauteng, South Africa, July 2014–October 2014*

Patient characteristics C. krusei candidemia, n = 48 No C. krusei candidemia, n = 541 Total p value
Sex
M 28/48 (58.3) 309/539 (57.3) 337/587 (57.4) 0.878
F
 20/48 (41.7)
 230/539 (42.7)
 250/587 (42.6)
Median chronological age at onset of candidemia, d (IQR) 13 (7.5–17) NA NA NA
Mean gestational age at birth, wk (±SD) 33 (±3.8) 35 (±4.1) 35 (±4.1) <0.001
Median birthweight, g (IQR) 1,365 (1,130–1,970) 2,300 (1,635–3,070) 2,225 (1,580–3,030) <0.001
Median length of hospital stay, d (IQR)
 39 (25–55)
 7 (1–17)
 8 (2–20)
 <0.001
Twin infants or triplets 4/48 (8.3) 54/541 (10) 58/589 (9.8) 1.000
Born in hospital A 42/46 (91.3) 490/541 (90.6) 532/587 (90.6) 1.000
Died
 7/48 (14.6)
 62/538 (11.5)
 69/586 (11.8)
 0.468
Received antibacterial drugs during hospital stay 40/41 (97.6) 28/41 (68.3) 68/82 (82.9) 0.001
Median no. (IQR) antibacterial drugs received in first 13 d 3 (2–3) 2 (0–3) 2 (0–3) 0.001
Received TPN during hospital stay 24/40 (60) 5/41 (12.2) 29/81 (35.8) <0.001
Received >1 blood transfusion during hospital stay 38/41 (92.7) 18/41 (43.9) 56/82 (68.3) <0.001

*Values are no. in category/total no. (%) except as indicated. Bold indicates statistically significant values. In the No C. krusei candidemia group, data were unavailable for the following variables: sex (n = 2), gestational age (n = 22), birthweight (n = 1), length of hospital stay (n = 3) and death (n = 3). In the C. krusei candidemia group, data was unavailable for the following variables: gestational age (n = 3), birthweight (n = 2), length of hospital stay (n = 4), place of birth (n = 2). Data for the following variables were only available for a subset of patients from the nested case-control study (cases: n = 41, controls: n = 41): antibacterial drugs during hospital stay, number of antibacterial drugs in first 13 d, TPN during hospital stay and blood transfusions.
IQR, interquartile range; NA, not applicable; TPN, total parenteral nutrition.

Main Article

Page created: June 14, 2018
Page updated: June 14, 2018
Page reviewed: June 14, 2018
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external