Volume 25, Number 4—April 2019
Research
Staphylococcus aureus Bacteremia in Children of Rural Areas of The Gambia, 2008–2015
Table 4
Antimicrobial drug | No. isolates tested | No. (%) sensitive | No. (%) intermediate | No. (%) resistant |
---|---|---|---|---|
Cefoxitin† | 193 | 187 (96.9) | 0 | 6 (3.1) |
Chloramphenicol | 186 | 176 (94.6) | 2 (1.1) | 8 (4.3) |
Cotrimoxazole | 180 | 119 (66.1) | 21 (11.7) | 40 (22.2) |
Erythromycin | 173 | 141 (81.5) | 24 (13.9) | 8 (4.6) |
Gentamicin | 177 | 174 (98.3) | 0 | 3 (1.7) |
Oxacillin | 194 | 170 (87.6) | 24 (12.4) | 0 |
Tetracycline | 180 | 128 (71.1) | 2 (1.1) | 50 (27.8) |
*Surveillance data are from the Basse Health and Demographic Surveillance System and the Fuladu West Health and Demographic Surveillance System.
†Cefoxitin was used as a surrogate for methicillin-resistant isolates as recommended by the Clinical and Laboratory Standards Institute (21).
References
- United Nations Inter-agency Group for Child Mortality Estimation. Levels & trends in child mortality report 2017. New York: United Nations Children’s Fund; 2017.
- Liu L, Johnson HL, Cousens S, Perin J, Scott S, Lawn JE, et al.; Child Health Epidemiology Reference Group of WHO and UNICEF. Global, regional, and national causes of child mortality: an updated systematic analysis for 2010 with time trends since 2000. Lancet. 2012;379:2151–61. DOIPubMedGoogle Scholar
- Blomberg B, Manji KP, Urassa WK, Tamim BS, Mwakagile DS, Jureen R, et al. Antimicrobial resistance predicts death in Tanzanian children with bloodstream infections: a prospective cohort study. BMC Infect Dis. 2007;7:43. DOIPubMedGoogle Scholar
- Berkley JA, Lowe BS, Mwangi I, Williams T, Bauni E, Mwarumba S, et al. Bacteremia among children admitted to a rural hospital in Kenya. N Engl J Med. 2005;352:39–47. DOIPubMedGoogle Scholar
- Oluwalana C, Howie SR, Secka O, Ideh RC, Ebruke B, Sambou S, et al. Incidence of Haemophilus influenzae type b disease in The Gambia 14 years after introduction of routine Haemophilus influenzae type b conjugate vaccine immunization. J Pediatr. 2013;163(Suppl):S4–7. DOIPubMedGoogle Scholar
- Mackenzie GA, Hill PC, Jeffries DJ, Hossain I, Uchendu U, Ameh D, et al. Effect of the introduction of pneumococcal conjugate vaccination on invasive pneumococcal disease in The Gambia: a population-based surveillance study. Lancet Infect Dis. 2016;16:703–11. DOIPubMedGoogle Scholar
- Waters D, Jawad I, Ahmad A, Lukšić I, Nair H, Zgaga L, et al. Aetiology of community-acquired neonatal sepsis in low and middle income countries. J Glob Health. 2011;1:154–70.PubMedGoogle Scholar
- Johnson AP, Pearson A, Duckworth G. Surveillance and epidemiology of MRSA bacteraemia in the UK. J Antimicrob Chemother. 2005;56:455–62. DOIPubMedGoogle Scholar
- Stoll BJ, Hansen NI, Sánchez PJ, Faix RG, Poindexter BB, Van Meurs KP, et al.; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Early onset neonatal sepsis: the burden of group B Streptococcal and E. coli disease continues. Pediatrics. 2011;127:817–26. DOIPubMedGoogle Scholar
- Cobos-Carrascosa E, Soler-Palacín P, Nieves Larrosa M, Bartolomé R, Martín-Nalda A, Antoinette Frick M, et al. Staphylococcus aureus bacteremia in Children: changes during eighteen years. Pediatr Infect Dis J. 2015;34:1329–34. DOIPubMedGoogle Scholar
- Mejer N, Westh H, Schønheyder HC, Jensen AG, Larsen AR, Skov R, et al.; Danish Staphylococcal Bacteraemia Study Group. Stable incidence and continued improvement in short term mortality of Staphylococcus aureus bacteraemia between 1995 and 2008. BMC Infect Dis. 2012;12:260. DOIPubMedGoogle Scholar
- Sigaúque B, Roca A, Mandomando I, Morais L, Quintó L, Sacarlal J, et al. Community-acquired bacteremia among children admitted to a rural hospital in Mozambique. Pediatr Infect Dis J. 2009;28:108–13. DOIPubMedGoogle Scholar
- Mulholland EK, Ogunlesi OO, Adegbola RA, Weber M, Sam BE, Palmer A, et al. Etiology of serious infections in young Gambian infants. Pediatr Infect Dis J. 1999;18(Suppl):S35–41. DOIPubMedGoogle Scholar
- Uzodimma CC, Njokanma F, Ojo O, Falase M, Ojo T. Bacterial isolates from blood cultures of children with suspected sepsis in an urban hospital in Lagos: a prospective study using BACTEC blood culture system. Internet J Pediatr Neonatol. 2013;16:1623.
- Groome MJ, Albrich WC, Wadula J, Khoosal M, Madhi SA. Community-onset Staphylococcus aureus bacteraemia in hospitalised African children: high incidence in HIV-infected children and high prevalence of multidrug resistance. Paediatr Int Child Health. 2012;32:140–6. DOIPubMedGoogle Scholar
- Hill PC, Onyeama CO, Ikumapayi UN, Secka O, Ameyaw S, Simmonds N, et al. Bacteraemia in patients admitted to an urban hospital in West Africa. BMC Infect Dis. 2007;7:2. DOIPubMedGoogle Scholar
- Scott S, Odutola A, Mackenzie G, Fulford T, Afolabi MO, Lowe Jallow Y, et al. Coverage and timing of children’s vaccination: an evaluation of the expanded programme on immunisation in The Gambia. PLoS One. 2014;9:e107280. DOIPubMedGoogle Scholar
- Mwesigwa J, Okebe J, Affara M, Di Tanna GL, Nwakanma D, Janha O, et al. On-going malaria transmission in The Gambia despite high coverage of control interventions: a nationwide cross-sectional survey. Malar J. 2015;14:314. DOIPubMedGoogle Scholar
- Mackenzie GA, Plumb ID, Sambou S, Saha D, Uchendu U, Akinsola B, et al. Monitoring the introduction of pneumococcal conjugate vaccines into West Africa: design and implementation of a population-based surveillance system. PLoS Med. 2012;9:e1001161. DOIPubMedGoogle Scholar
- Adegbola RA, Falade AG, Sam BE, Aidoo M, Baldeh I, Hazlett D, et al. The etiology of pneumonia in malnourished and well-nourished Gambian children. Pediatr Infect Dis J. 1994;13:975–82. DOIPubMedGoogle Scholar
- Clinical and Laboratory Standards Institute. Performance standards for antimicrobial disk susceptibility tests; approved standard—twelfth edition (M02-A12). Wayne (PA): The Institute; 2015.
- Frederiksen MS, Espersen F, Frimodt-Møller N, Jensen AG, Larsen AR, Pallesen LV, et al. Changing epidemiology of pediatric Staphylococcus aureus bacteremia in Denmark from 1971 through 2000. Pediatr Infect Dis J. 2007;26:398–405. DOIPubMedGoogle Scholar
- Asgeirsson H, Gudlaugsson O, Kristinsson KG, Vilbergsson GR, Heiddal S, Haraldsson A, et al. Low mortality of Staphylococcus aureus bacteremia in Icelandic children: nationwide study on incidence and outcome. Pediatr Infect Dis J. 2015;34:140–4. DOIPubMedGoogle Scholar
- Kanoksil M, Jatapai A, Peacock SJ, Limmathurotsakul D. Epidemiology, microbiology and mortality associated with community-acquired bacteremia in northeast Thailand: a multicenter surveillance study. PLoS One. 2013;8:e54714. DOIPubMedGoogle Scholar
- Arifeen SE, Saha SK, Rahman S, Rahman KM, Rahman SM, Bari S, et al. Invasive pneumococcal disease among children in rural Bangladesh: results from a population-based surveillance. Clin Infect Dis. 2009;48(Suppl 2):S103–13. DOIPubMedGoogle Scholar
- Zellweger RM, Carrique-Mas J, Limmathurotsakul D, Day NPJ, Thwaites GE, Baker S, et al.; Southeast Asia Antimicrobial Resistance Network. A current perspective on antimicrobial resistance in Southeast Asia. J Antimicrob Chemother. 2017;72:2963–72. DOIPubMedGoogle Scholar
- Greenhow TL, Hung YY, Herz A. Bacteremia in Children 3 to 36 months old after introduction of conjugated pneumococcal vaccines. Pediatrics. 2017;139:e20162098. DOIPubMedGoogle Scholar
- Peacock SJ, Justice A, Griffiths D, de Silva GD, Kantzanou MN, Crook D, et al. Determinants of acquisition and carriage of Staphylococcus aureus in infancy. J Clin Microbiol. 2003;41:5718–25. DOIPubMedGoogle Scholar
- Power Coombs MR, Kronforst K, Levy O. Neonatal host defense against Staphylococcal infections. Clin Dev Immunol. 2013;2013:826303. DOIPubMedGoogle Scholar
- Trijbels-Smeulders M, de Jonge GA, Pasker-de Jong PC, Gerards LJ, Adriaanse AH, van Lingen RA, et al. Epidemiology of neonatal group B streptococcal disease in the Netherlands before and after introduction of guidelines for prevention. Arch Dis Child Fetal Neonatal Ed. 2007;92:F271–6. DOIPubMedGoogle Scholar
- Bojang A, Kendall L, Usuf E, Egere U, Mulwa S, Antonio M, et al. Prevalence and risk factors for Staphylococcus aureus nasopharyngeal carriage during a PCV trial. BMC Infect Dis. 2017;17:588. DOIPubMedGoogle Scholar
- Wang X, Zhang N, Glorieux S, Holtappels G, Vaneechoutte M, Krysko O, et al. Herpes simplex virus type 1 infection facilitates invasion of Staphylococcus aureus into the nasal mucosa and nasal polyp tissue. PLoS One. 2012;7:e39875. DOIPubMedGoogle Scholar
- Lewis SS, Walker VJ, Lee MS, Chen L, Moehring RW, Cox CE, et al. Epidemiology of methicillin-resistant Staphylococcus aureus pneumonia in community hospitals. Infect Control Hosp Epidemiol. 2014;35:1452–7. DOIPubMedGoogle Scholar
- Breiman RF, Cosmas L, Njenga M, Williamson J, Mott JA, Katz MA, et al. Severe acute respiratory infection in children in a densely populated urban slum in Kenya, 2007-2011. BMC Infect Dis. 2015;15:95. DOIPubMedGoogle Scholar
Page created: March 17, 2019
Page updated: March 17, 2019
Page reviewed: March 17, 2019
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.