Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 27, Number 11—November 2021
Research

Population Genomics and Inference of Mycobacterium avium Complex Clusters in Cystic Fibrosis Care Centers, United States

Nabeeh A. Hasan1Comments to Author , Rebecca M. Davidson1, L. Elaine Epperson, Sara M. Kammlade, Sean Beagle, Adrah R. Levin, Vinicius Calado de Moura, Joshua J. Hunkins, Natalia Weakly, Scott D. Sagel, Stacey L. Martiniano, Max Salfinger, Charles L. Daley, Jerry A. Nick, and Michael Strong
Author affiliations: National Jewish Health, Denver, Colorado, USA (N.A. Hasan, R.M. Davidson, L.E. Epperson, S.M. Kammlade, S. Beagle, A.R. Levin, V. Calado de Moura, J.J. Hunkins, N. Weakly, C.L. Daley, J.A. Nick, M. Strong); University of Colorado Anschutz Medical Campus and Children’s Hospital Colorado, Aurora, Colorado, USA (S.D. Sagel, S.L. Martiniano); University of South Florida College of Public Health and Morsani College of Medicine, Tampa, Florida, USA (M. Salfinger)

Main Article

Figure 6

Genetic clusters of Mycobacterium avium, M. intracellulare subspecies chimaera, and M. intracellulare subsp. intracellulare in persons with CF in a study of Mycobacterium avium complex clusters in cystic fibrosis centers, United States. Three clusters of M. avium, 5 clusters of M. intracellulare subsp. chimaera, and 10 clusters of M. intracellulare subsp. intracellulare were identified. Each node represents a patient with >1 isolate having significant genetic similarity to an isolate in >1 patient. The color of each node represents the state of the submitting CF care center. Each edge represents genetic similarity between the isolates. Connecting edges are colored by matches within a center (red) or between different centers (dashed gray), and edge thickness is weighted from 0 SNPs (thickest) to 20 SNPs (thinnest) and the exact number of SNPs specified. Nodes with multiple connecting edges represent multiple isolates matching between patients. CF, cystic fibrosis; SNP, single-nucleotide polymorphism.

Figure 6. Genetic clusters of Mycobacterium avium, M. intracellulare subspecies chimaera, and M. intracellulare subsp. intracellulare in persons with CF in a study of Mycobacterium avium complex clusters in cystic fibrosis centers, United States. Three clusters of M. avium, 5 clusters of M. intracellulare subsp. chimaera, and 10 clusters of M. intracellulare subsp. intracellulare were identified. Each node represents a patient with >1 isolate having significant genetic similarity to an isolate in >1 patient. The color of each node represents the state of the submitting CF care center. Each edge represents genetic similarity between the isolates. Connecting edges are colored by matches within a center (red) or between different centers (dashed gray), and edge thickness is weighted from 0 SNPs (thickest) to 20 SNPs (thinnest) and the exact number of SNPs specified. Nodes with multiple connecting edges represent multiple isolates matching between patients. CF, cystic fibrosis; SNP, single-nucleotide polymorphism.

Main Article

1These first authors contributed equally to this article.

Page created: September 16, 2021
Page updated: October 19, 2021
Page reviewed: October 19, 2021
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external