Volume 27, Number 3—March 2021
Research Letter
COVID-19–Associated Fusobacterium nucleatum Bacteremia, Belgium
Table
Characteristics of 4 cases of Fusobacterium nucleatum bacteremia in patients with COVID-19, Belgium*
| Characteristic | Patient 1 | Patient 2 | Patient 3 | Patient 4 |
|---|---|---|---|---|
| Age, y |
52 |
51 |
34 |
70 |
| COVID-19 diagnosis |
Day of admission |
Day of admission |
Day of admission |
Day of admission |
| Symptoms at diagnosis |
Dry cough and sore throat for 7 d |
Cough, abdominal pain, and diarrhea for 7 d |
Cough, abdominal pain, and diarrhea for 7 d |
Fever (38.5°C),
vomiting for 1 d |
| Underlying conditions |
Hypertension |
Diabetes, hypertension, obesity |
None |
Diabetes, hypertension, hypothyroidism, history of stroke |
| Radiological findings | ||||
| Chest CT | Ground glass opacities in all lobes | Diffuse infiltrates in all lobes | Ground glass opacities in 10% of lungs | Ground glass opacities in 10% of lungs |
| Abdominal CT with contrast |
NA |
NA |
Unremarkable |
Unremarkable |
| Blood culture collection | Day 1 | Day 15 | Day 1 | Day 1 |
| Time to positivity (no. sets) |
96 h (1 of 2) |
55 h (1 of 2) |
72 h (1 of 2) |
72 h (1 of 2) |
| COVID-19 therapy |
HCQ 400 mg oral 2×/d on day 1, then 200 mg 2×/d for 4 d |
HCQ 400 mg oral 2×/d on day 1, then 200 mg 2×/d for 4 d; TCZ 800 mg IV once; and RDV 200 mg IV loading dose, then 100 mg 4×/d for 4 d |
None |
None |
| Antimicrobial drug therapy |
None |
TZP 4 g IV 4×/d for 6 d |
MTZ 500 mg orally 3×/d for 7 d |
None |
| F. nucleatum antimicrobial susceptibility testing | ||||
| Amoxicillin/clavulanic | S | S | S | S |
| Clindamycine | S | S | S | S |
| Imipenem | S | S | S | S |
| Metronidazole | S | S | S | S |
| Piperacilline/tazobactam |
S |
S |
S |
S |
| Outcome | Discharged home | Died | Discharged home | Discharged home |
*COVID-19, coronavirus disease; CT, computed tomography; HCQ, hydroxychloroquine; IV, intravenous; MTZ, metronidazole; RDV, remdesivir; S, susceptible; TCZ, tocilizumab; TZP, piperacilline-tazobactam.
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CrossMark reports this article was originally posted as a Preprint at https://doi.org/10.1101/2020.02.17.20023721. (Ref. 4 "Xiao, Tang, Zheng, Liu, Li, Shan, 2020")
CrossMark reports this article was originally posted as a Preprint at https://doi.org/10.1101/2020.04.25.060350. (Ref. 7 "Lamers, Beumer, van der Vaart, Knoops, Puschhof, Breugem, et al., 2020")
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