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Volume 28, Number 3—March 2022
Research Letter

Sensitivity of Mycobacterium leprae to Telacebec

Ramanuj LahiriComments to Author , Linda B. Adams, Sangeeta Susan Thomas, and Kevin PetheComments to Author 
Author affiliations: US Department of Health and Human Services, Health Resources and Services Administration, Health Systems Bureau, National Hansen's Disease Program, Baton Rouge, Louisiana, USA (R. Lahiri, L.B. Adams); Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore (S.S. Thomas, K. Pethe)

Main Article

Figure

Efficacy of telacebec against Mycobacterium leprae bacteria in axenic culture (A), in murine bone marrow–derived macrophages (B), and in athymic nude mouse foot pad model (C, D). M. leprae hsp18 (C) and esxA (D) expression levels were used as a surrogate measure of viability. For panels A and B, the assays were performed in triplicate for each condition. For panels C and D, each foot pad is taken as a data point, and the red dotted lines indicate ≈99% M. leprae kill. Significance was determined by 2-tailed unpaired Student t-test. 14C, carbon 14; CPM, counts per minute; Q203, telacebec; RMP, rifampin.

Figure. Efficacy of telacebec against Mycobacterium leprae bacteria in axenic culture (A), in murine bone marrow–derived macrophages (B), and in athymic nude mouse foot pad model (C, D). M. leprae hsp18 (C) and esxA (D) expression levels were used as a surrogate measure of viability. For panels A and B, the assays were performed in triplicate for each condition. For panels C and D, each foot pad is taken as a data point, and the red dotted lines indicate ≈99% M. leprae kill. Significance was determined by 2-tailed unpaired Student t-test. 14C, carbon 14; CPM, counts per minute; Q203, telacebec; RMP, rifampin.

Main Article

Page created: February 02, 2022
Page updated: February 21, 2022
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