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Volume 28, Number 4—April 2022
Research

Fatal Human Alphaherpesvirus 1 Infection in Free-Ranging Black-Tufted Marmosets in Anthropized Environments, Brazil, 2012–2019

Tais M. Wilson, Jana M. Ritter, Roosecelis B. Martines, Hannah A. Bullock, Pamela Fair, Kay W. Radford, Isabel L. Macêdo, Davi E.R. Sousa, Alexandra A.B. Gonçalves, Alessandro P. Romano, Pedro H.O. Passsos, Daniel G. Ramos, Gabriela R.T. Costa, Karina R.L.J. Cavalcante, Cristiano B. de Melo, Sherif R. Zaki, and Marcio B. CastroComments to Author 
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (T.M. Wilson, J.M. Ritter, R.B. Martines, P. Fair, K.W. Radford, S.R. Zaki); University of Brasília, Brasília, Brazil (T.M. Wilson, I.L. Macêdo, D.E.R. Sousa, A.A.B. Gonçalves, C.B. de Melo, M.B. Castro); Synergy America Inc., Atlanta (H.A. Bullock); Brazilian Ministry of Health, Brasília (A.P. Romano, P.H.O. Passos, D.G. Ramos, K.R.L.J. Cavalcante); Environmental Health Surveillance Directorate of the Federal District, Brasilia (G.R.T. Costa)

Main Article

Figure 5

Liver pathology in free-ranging black-tufted marmosets with fatal human alphaherpesvirus 1 infection, Brazil, 2012–2019. A) Intranuclear inclusion bodies in hepatocytes at the margin of a necrotic focus. Hemotoxylin and eosin (H&E) stain; original magnification ×63. B) Multinucleated syncytial cell (arrow). H&E; original magnification ×63. C) Human alphaherpesvirus 1 immunostaining within hepatocytes in an area of necrotizing hepatitis. Immunihistochemistry; original magnification ×40. D) Herpesvirus in the cytoplasm of a hepatocyte. Transmission electron microscopy; scale bar indicates 400 nm.

Figure 5. Liver pathology in free-ranging black-tufted marmosets with fatal human alphaherpesvirus 1 infection, Brazil, 2012–2019. A) Intranuclear inclusion bodies in hepatocytes at the margin of a necrotic focus. Hemotoxylin and eosin (H&E) stain; original magnification ×63. B) Multinucleated syncytial cell (arrow). H&E; original magnification ×63. C) Human alphaherpesvirus 1 immunostaining within hepatocytes in an area of necrotizing hepatitis. Immunihistochemistry; original magnification ×40. D) Herpesvirus in the cytoplasm of a hepatocyte. Transmission electron microscopy; scale bar indicates 400 nm.

Main Article

Page created: January 26, 2022
Page updated: March 19, 2022
Page reviewed: March 19, 2022
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