Volume 28, Number 5—May 2022
Research
Effectiveness of BNT162b2 Vaccine Booster against SARS-CoV-2 Infection and Breakthrough Complications, Israel
Aharona Glatman-Freedman
, Michal Bromberg, Yael Hershkovitz, Hanna Sefty, Zalman Kaufman, Rita Dichtiar, and Lital Keinan-Boker
, Michal Bromberg, Yael Hershkovitz, Hanna Sefty, Zalman Kaufman, Rita Dichtiar, and Lital Keinan-Boker
Table 3
Rate reduction of deaths among SARS-CoV-2–positive persons who received the BNT162b2 COVID-19 vaccine booster dose, Israel*
| Age group, y | Time of first positive SARS-CoV-2 PCR test after index date, wk |
Unvaccinated SARS-CoV-2–positive persons |
Vaccinated SARS-CoV-2–positive persons |
Adjusted 1 – IRR, % (95% CI)† | |||
|---|---|---|---|---|---|---|---|
| Deaths | Total | Deaths | Total | ||||
| 16–59 | 2 | 45 | 22,545 | 0 | 1,343 | 100 | |
| 3 | 36 | 18,232 | 0 | 455 | 100 | ||
| 4 | 27 | 12,962 | 0 | 293 | 100 | ||
| 5 | 17 | 8,555 | 0 | 210 | 100 | ||
| 6 | 11 | 5,531 | 0 | 138 | 100 | ||
| 7 | 6 | 3,573 | 0 | 131 | 100 | ||
| 8 | 5 | 2,626 | 0 | 83 | 100 | ||
| 9 | 4 | 2,013 | 0 | 54 | 100 | ||
| 10 | 3 | 1,714 | 0 | 57 | 100 | ||
| 11 | 3 | 1,401 | 0 | 66 | 100 | ||
| 12 | 3 | 1,385 | 0 | 90 | 100 | ||
| 13 | 2 | 1,442 | 0 | 118 | 100 | ||
| 14 | 1 | 1,569 | 0 | 154 | 100 | ||
| 15 | 1 | 2,145 | 0 | 351 | 100 | ||
| 16 | 1 | 4,088 | 0 | 884 | 100 | ||
| 2–16 combined |
72 |
41,135 |
0 |
4,427 |
100 |
||
| >60 | 2 | 243 | 1,985 | 31 | 1,314 | 81.9 (70.4–88.9) | |
| 3 | 246 | 2,200 | 13 | 464 | 76.0 (55.3–87.2) | ||
| 4 | 226 | 2,160 | 13 | 375 | 68.1 (49.6–79.8) | ||
| 5 | 229 | 2,164 | 11 | 319 | 68.7 (42.7–82.9) | ||
| 6 | 201 | 2,033 | 7 | 296 | 76.5 (55.9–87.4) | ||
| 7 | 166 | 1,724 | 8 | 271 | 70.5 (29.4–87.7) | ||
| 8 | 122 | 1,276 | 8 | 221 | 63.1 (29.4–80.7) | ||
| 9 | 89 | 869 | 2 | 147 | 87.6 (53.7–96.7) | ||
| 10 | 59 | 577 | 5 | 86 | 49.1 (−44.3 to 82.1) | ||
| 11 | 30 | 376 | 0 | 63 | 100.0 | ||
| 12 | 19 | 258 | 1 | 44 | 67.7 (−189.8 to 96.4) | ||
| 13 | 19 | 208 | 1 | 52 | 78.7 (−89.9 to 97.6) | ||
| 14 | 22 | 183 | 1 | 49 | 85.0 (8.5–97.5) | ||
| 15 | 21 | 170 | 1 | 47 | 85.3 (−21.3 to 98.2) | ||
| 16 | 17 | 162 | 0 | 44 | 100.0 | ||
| 17 | 11 | 151 | 1 | 56 | 74.6 (−225.9 to 98.0) | ||
| 18 | 10 | 147 | 0 | 69 | 100.0 | ||
| 19 | 7 | 184 | 2 | 125 | 56.5 (−144.3 to 92.3) | ||
| 20 | 8 | 305 | 3 | 432 | 70.7 (−2.7 to 91.7) | ||
| 2–20 combined | 686 | 6,673 | 108 | 4,474 | 77.1 (71.2–81.8) | ||
*COVID-19, coronavirus disease; IRR, incidence rate ratio; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2. †Adjusted for sex and epidemiologic week.
Page created: March 18, 2022
Page updated: April 19, 2022
Page reviewed: April 19, 2022
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