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Volume 30, Number 10—October 2024
Research

Virulence of Burkholderia pseudomallei ATS2021 Unintentionally Imported to United States in Aromatherapy Spray

Christopher K. CoteComments to Author , Kevin D. Mlynek, Christopher P. Klimko, Sergei S. Biryukov, Sherry Mou, Melissa Hunter, Nathaniel O. Rill, Jennifer L. Dankmeyer, Jeremy A. Miller, Yuli Talyansky, Michael L. Davies, J. Matthew Meinig, Stephanie A. Halasohoris, Annette M. Gray, Jade L. Spencer, Ashley L. Babyak, M. Kelly Hourihan, Bobby J. Curry, Ronald G. Toothman, Sara I. Ruiz, Xiankun Zeng, Keersten M. Ricks, Tamara L. Clements, Christina E. Douglas, Suma Ravulapalli, Christopher P. Stefan, Charles J. Shoemaker, Mindy G. Elrod, Jay E. Gee, Zachary P. Weiner, Ju Qiu, Joel A. Bozue, Nancy A. Twenhafel, and David DeShazerComments to Author 
Author affiliations: United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA (C.K. Cote, K.D. Mlynek, C.P. Klimko, S.S. Biryukov, S. Mou, M. Hunter, N.O. Rill, J.L. Dankmeyer, J.A. Miller, Y. Talyansky, M.L. Davies, J.M. Meinig, S.A. Halasohoris, A.M. Gray, J.L. Spencer, A.L. Babyak, M.K. Hourihan, B.J. Curry, R.G. Toothman, S.I. Ruiz, X. Zeng, K.M. Ricks, T.L. Clements, C.E. Douglas, S. Ravulapalli, C.P. Stefan, C.J. Shoemaker, J. Qiu, J.A. Bozue, N.A. Twenhafel, D. DeShazer); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (M.G. Elrod, J.E. Gee, Z.P. Weiner)

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Table

Median lethal dose of aerosolized Burkholderia mallei ATS2021 in C57BL/6 and BALB/c mice*

Mice† Day Inhaled dose LD50 (95% CI) TTD median (95% CI) TTD mean (SE)
C57BL/6
 21 9.9 × 10–1 56.4 CFU (21.3–150.2) >21 >21
1.32 × 101 >21 16.5 (0.7)
1.07 × 102 18.0 (11.0–NC) 15.9 (0.9)
1.15 × 103 4.0 (3.0–5.0) 4.4 (0.3)
4.49 × 103 3.0 (NC) 3.1 (0.1)
60
 9.9 × 10–1 5.8 CFU (2.0–15.1)
 >60 51.0 (NC)
1.32 × 101 41.5 (12.0– NC) 39.3 (5.6)
1.07 × 102 18.0 (11.0–26.0) 20.9 (3.2)
1.15 × 103 4.0 (3.0–5.0) 4.4 (0.3)
4.49 × 103
 3.0 (NC)
 3.1 (0.1)
BALB/c 21 4.00 × 10–1 4.1 CFU (1.8–11.3) >21 4.0 (NC)
2 >21 4.9 (0.1)
2.05 × 101 4.0 (3.0 –4.0) 4.3 (0.3)
1.86 × 102 3.0 (NC) 3.1 (0.1)
9.60 × 102 3.0 (2.0–3.0) 2.9 (0.1)
60 4.00 × 10–1 4.1 CFU (1.8–11.3) >60 4.0 (NC)
2 >60 4.9 (0.1)
2.05 × 101 4.0 (3.0–4.0) 4.3 (0.3)
1.86E × 102 3.0 (NC) 3.1 (0.1)
9.60 × 102 3.0 (2.0–3.0) 2.9 (0.1)

*LD50, 50% lethal dose; NC, noncalculable; TTD, time to death or euthanasia in accordance with early intervention criteria. †Female; 7–9 weeks of age at time of exposure to aerosolized bacteria.

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Page created: September 11, 2024
Page updated: September 23, 2024
Page reviewed: September 23, 2024
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