Volume 30, Number 10—October 2024
Research
Temporal Characterization of Prion Shedding in Secreta of White-Tailed Deer in Longitudinal Study of Chronic Wasting Disease, United States
Nathaniel D. Denkers, Erin E. McNulty, Caitlyn N. Kraft, Amy V. Nalls, Joseph A. Westrich, Edward A. Hoover, and Candace K. Mathiason
Table 1
Summary of collected tissues and secreta in longitudinal study of temporal characterization of prion shedding in white-tailed deer with chronic wasting disease, United States*
| mpi | 96GG genotype |
96GS/103NT genotypes |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. deer | Tonsil | RAMALT | Urine | Saliva | Feces | No. deer | Tonsil | RAMALT | Urine | Saliva | Feces | ||
| 6 | 6 | 1/6 | 0/6 | ND | 0/6 | 1/5 | 6 | 0/6 | 0/6 | ND | 0/6 | 1/2 | |
| 9 | 6 | 3/6 | 2/6 | 0/1 | 2/6 | 1/4 | 6 | 0/6 | 1/6 | 0/3 | 0/6 | 0/3 | |
| 12 | 6 | 3/6 | 3/6 | 0/3 | 2/6 | 2/5 | 6 | 0/6 | 1/6 | 0/6 | 0/6 | 0/5 | |
| 15 | 6 | 4/6 | 4/6 | 0/1 | 1/6 | 4/6 | 6 | 1/6 | 0/6 | 0/4 | 0/6 | 0/4 | |
| 18 | 6 | 6/6 | 5/6 | 1/2 | 1/6 | 4/5 | 6 | 1/6 | 1/6 | 0/3 | 0/6 | 0/5 | |
| 21 | 6 | 6/6 | 6/6 | 1/1 | 2/5 | 5/5 | 6 | 3/6 | 1/6 | 0/5 | 1/6 | 0/6 | |
| 24 | 5 | 5/5 | 5/5 | 3/4 | 2/4 | 4/5 | 6 | 5/5 | 4/6 | 0/5 | 1/6 | 1/4 | |
| 27 | 3 | 3/3 | 3/3 | 1/1 | 1/3 | 2/3 | 6 | 6/6 | 5/6 | 1/5 | 1/6 | 1/4 | |
| 29 | 2 | 2/2 | 2/2 | 1/1 | 2/2 | 1/1 | 6 | 6/6 | 6/6 | 0/5 | 3/6 | 1/4 | |
| 32 | 1 | 1/1 | 1/1 | 0/0 | 1/1 | 1/1 | 3 | 3/3 | 3/3 | 0/2 | 0/3 | 0/2 | |
| 35 | 1 | 1/1 | 1/1 | 1/1 | 1/1 | 1/1 | 3 | 3/3 | 3/3 | 0/2 | 0/3 | 1/2 | |
| 39 | 1 | 1/1 | 1/1 | 1/1 | 0/1 | 1/1 | 3 | 3/3 | 3/3 | 0/3 | 0/3 | 2/3 | |
| 42 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 2/2 | 2/2 | 0/2 | 0/2 | 1/2 | |
| 45 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 2/2 | 2/2 | 0/2 | 1/2 | 1/2 | |
| 48 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 2/2 | 2/2 | 0/2 | 1/2 | 1/2 | |
| 66 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1/1 | 1/1 | 0/1 | 0/1 | 0/1 | |
*Values are number of positive samples over total number of samples collected at each timepoint. Tissues and secreta from deer with wild-type genotype 96GG or alternative genotypes 96GS or 103NT of the prion protein gene were compared. mpi, months postinoculation; ND, not done; RAMALT, recto-anal mucosa-associated lymphoid tissue.
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