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Volume 30, Number 11—November 2024
Dispatch

Analysis of Monkeypox Virus Exposures and Lesions by Anatomic Site

Sarah Anne J. GuagliardoComments to Author , Teresa Smith, Davidson H. Hamer, Ralph Huits, Phyllis Kozarsky, Michael Libman, Andrea M. McCollum, Kristina M. Angelo, and GeoSentinel Network Collaborators1
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (S.A.J. Guagliardo, T. Smith, A.M. McCollum, K.M. Angelo); Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA (D.H. Hamer); Boston University Center on Emerging Infectious Diseases, Boston (D.H. Hamer); IRCCS Sacro Cuore Don Calabria Hospital, Verona, Italy (R. Huits); Emory University, Atlanta (P. Kozarsky); McGill University Health Centre, Montreal, Quebec, Canada (M. Libman)

Main Article

Table 2

Logistic regression models assessing the relationship between exposures, lesion presence or absence, and lesion onset site by anatomic site among patients with monkeypox virus who reported to GeoSentinel, May–July 2022*

No. pts.† Outcome (no. pts.)‡ Predictor No. pts.§ Univariable models
 Multivariable models¶
OR (95% CI) p value AIC aOR (95% CI) p value AIC
221
 Penis lesions (101)
 Penis exposure 138 3.7 (2.1–6.8) <0.001 288.4 14.6 (5.6–45.0) <0.0001 272.4
Rectum/anus exposure 110 0.7 (0.4–1.2) 0.25 307.4 0.3 (0.1–0.7) <0.01
Mouth exposure
 116
 1.2
 (0.7–2.0)
 0.59
 308.5
0.4
 (0.1–0.9)
 0.056
218
 Anal lesions (60)
 Rectum/anus exposure 110 4.8 (2.5–9.8) <0.0001 236.84 12.8 (4.8–39.8) <0.0001 229.4
Penis exposure 138 0.9 (0.5–1.7) 0.76 260.4 0.3 (0.1–0.4) <0.05
Mouth exposure
 116
 1.5
 (0.8–2.7)
 0.21
 259
0.6
 (0.2–1.9)
 0.41
221
 Mouth lesions (43)
 Mouth exposure 116 1.5 (0.8–3.0) 0.24 220.4 5.4 (1.7–19.7) <0.01 216.2
Penis exposure 138 0.7 (0.4–1.4) 0.31 220.8 0.3 (0.2–0.5) <0.05
Rectum/anus exposure
 110
 0.9
 (0.4–1.7)
 0.63
 221.6
0.5
 (0.2–1.3)
 0.17
226
 Penis lesions first (41)
 Penis exposure 138 3.4 (1.4–7.6) <0.01 209.4 7.3 (2.7–21.2) <0.001 204.3
Rectum/anus exposure 110 0.7 (0.3–1.4) 0.3 216.9 0.5 (0.2–1.1) 0.078
Mouth exposure
 116
 1.0
 (0.5–2.0)
 0.9
 218.0
0.5
 (0.2–1.3)
 0.17
226
 Anus lesions first (30)
 Rectum/anus exposure 110 2.4 (1.1–5.5) 0.038 176.4 3.7 (1.3–11.2) <0.05 176.9
Penis exposure 138 0.8 (0.4–1.8) 0.60 180.7 0.4 (0.1–1.2) 0.11
Mouth exposure
 116
 1.3
 (0.6–2.8)
 0.53
 180.6
1.1
 (0.3–3.9)
 0.91
226 Mouth lesions first (25) Mouth exposure 116 0.9 (0.4–2.0) 0.72 161.1 3.1 (0.8–13.1) 0.11 158.9
Penis exposure 138 0.5 (0.2–1.3) 0.16 159.4 0.4 (0.1–1.3) 0.15
Rectum/anus exposure 110 0.5 (0.2–1.1) 0.083 158.0 0.3 (0.1–1.0) 0.06

*For each model, the main predictor variable of interest is listed first, followed by additional predictor variables. AIC, akaike information criterion; aOR, adjusted odds ratio; OR, odds ratio; pts., patients. †The number of observations included in the regression model. Missing observations: n = 5 for penis lesions, n = 8 for anus lesions, n = 5 for mouth lesions. ‡The number of patients who reported lesions at this anatomic site. §The number of patients who reported exposure at this anatomic site. ¶Covariates included in each multivariable model are all exposure types (e.g., for the outcome of penis lesions, penile, anorectal and oral exposures were included).

Main Article

1GeoSentinel Network Collaborators are listed at the end of this article.

Page created: September 27, 2024
Page updated: October 22, 2024
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