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Volume 30, Number 7—July 2024
Dispatch

Evidence of Orientia spp. Endemicity among Severe Infectious Disease Cohorts, Uganda

Paul W. BlairComments to Author , Kenneth Kobba, Stephen Okello, Sultanah Alharthi, Prossy Naluyima, Emily Clemens, Hannah Kibuuka, Danielle V. Clark, Francis Kakooza, Mohammed Lamorde, Yukari C. Manabe, J. Stephen Dumler, Acute Febrile Illness, and Sepsis in Uganda study teams1
Author affiliations: Uniformed Services University, Bethesda, Maryland, USA (P.W. Blair, S. Alharthi, E. Clemens, J.S. Dumler); Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda (P.W. Blair, S. Alharthi, D.V. Clark); Johns Hopkins University School of Medicine, Baltimore, Maryland, USA (P.W. Blair, Y.C. Manabe); Infectious Diseases Institute, Makerere University, Kampala, Uganda (K. Kobba, F. Kakooza, M. Lamorde); Makerere University Walter Reed Project, Kampala (S. Okello, P. Naluyima, H. Kibuuka)

Main Article

Table 1

Rickettsia IgG results from participants with Orientia spp. seroconversion in a study of Orientia genus endemicity among severe infectious disease cohorts, Uganda*

Participant Days after illness onset†
 Orientia spp.–positive titer‡
 Spotted fever group titer
 Typhus group titer
Acute Conv. Fold change Acute Conv. Fold change Acute Conv. Fold change Acute Conv.
Mubende
A
 7
 34
4
 256
 1,024
1
 32
 32
1
 32
 32
Fort Portal
B 2 32 8 64 512 1 32 32 1 32 32
C 14 36 4 128 512 1 32 32 1 32 32
D 1 38 4 128 512 1 32 32 1 32 32

*Conv., convalescent; IFA, immunofluorescent assay. †Sample collection after illness onset. ‡Karp strain IFA. Gilliam strain IFA seroconversion also observed in Fort Portal participant D (acute titers 1:512 and convalescent titers 1:2,048) but not among participants A-C.

Main Article

1Members of the Acute Febrile Illness and Sepsis in Uganda study teams are listed at the end of this article.

Page created: May 10, 2024
Page updated: June 22, 2024
Page reviewed: June 22, 2024
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