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Volume 30, Number 8—August 2024
Research

Potential of Pan-Tuberculosis Treatment to Drive Emergence of Novel Resistance

C. Finn McQuaidComments to Author , Theresa S. Ryckman, Nicolas A. Menzies, Richard G. White, Ted Cohen, and Emily A. Kendall
Author affiliations: London School of Hygiene and Tropical Medicine, London, UK (C.F. McQuaid, R.G. White); Johns Hopkins University School of Medicine, Baltimore, Maryland, USA (T.S. Ryckman, E.A. Kendall); Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA (N.A. Menzies); Yale School of Public Health, New Haven, Connecticut, USA (T. Cohen)

Main Article

Figure 2

Prevalence of resistance phenotypes over multiple cohorts of TB treatment in study of potential of pan-TB treatment to drive emergence of novel resistance for standard-of-care (A) and pan-TB (B) treatment scenarios. Shaded areas indicate 95% CIs. x-axis indicates scale indicates treatment generations. BR/XR, TB resistant to a diarylquinoline or novel drug X or both only; DS, drug-susceptible TB; RR, rifampin-resistant TB; RR+BR/XR, TB resistant both to rifampin and to either a diarylquinoline, novel drug X, or both; TB, tuberculosis.

Figure 2. Prevalence of resistance phenotypes over multiple cohorts of TB treatment in study of potential of pan-TB treatment to drive emergence of novel resistance for standard-of-care (A) and pan-TB (B) treatment scenarios. Shaded areas indicate 95% CIs. x-axis indicates scale indicates treatment generations. BR/XR, TB resistant to a diarylquinoline or novel drug X or both only; DS, drug-susceptible TB; RR, rifampin-resistant TB; RR+BR/XR, TB resistant both to rifampin and to either a diarylquinoline, novel drug X, or both; TB, tuberculosis.

Main Article

Page created: June 21, 2024
Page updated: July 20, 2024
Page reviewed: July 20, 2024
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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