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Volume 31, Supplement—April 2025
SUPPLEMENT ISSUE
Supplement
Successful Transition to Whole-Genome Sequencing and Bioinformatics to Identify Invasive Streptococcus spp. Drug Resistance, Alaska, USA
Karen M. Miernyk
, Sopio Chochua, Ben Metcalf, Alisa Reasonover, and Brenna Simons-Petrusa
, Sopio Chochua, Ben Metcalf, Alisa Reasonover, and Brenna Simons-Petrusa
Table 4
Discordant Streptococcus pneumoniae β-lactam resistance predicted by penicillin-binding protein sequences compared with phenotypic testing results, Alaska, 1986–2021*
| Antimicrobial drug | WGS predicted MIC, μg/mL | Initial phenotypic MIC, μg/mL | Follow-up testing for ≥2 dilution discrepancy |
||
|---|---|---|---|---|---|
| MIC, μg/mL | Agrees with WGS, no. | True discrepancy, no. | |||
| Meropenem |
1, R |
0.25, S |
1, R |
1 |
0 |
| Ceftriaxone† | 1, I/S | <0.5, S/S | 1, I/S | 2 | 0 |
| 1, I/S | <0.5, S/S | 0.019, S/S | 0 | 1 | |
*I, intermediate resistance; R, resistant; S, susceptible; WGS, whole-genome sequencing. †Determined by using the Clinical and Laboratory Standards Institute (https://www.clsi.org) breakpoints for meningitis/nonmeningitis cases.
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