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Volume 31, Number 5—May 2025
CME ACTIVITY - Synopsis

Features of Invasive Aspergillosis Caused by Aspergillus flavus, France, 2012–2018

Lise Bertin-Biasutto, Olivier Paccoud, Dea Garcia-Hermoso, Blandine Denis, Karine Boukris-Sitbon, Olivier Lortholary, Stéphane Bretagne, Maud Gits-Muselli, Raoul Herbrecht, Valérie Letscher-Bru, François Danion, Sophie Cassaing, Florent Morio, Céline Nourrisson, Marc Pihet, Milène Sasso, Guillaume Desoubeaux, Marie-Fleur Durieux, Julie Bonhomme, Elisabeth Chachaty, Taieb Chouaki, Nicole Desbois-Nogard, Alexandre Alanio1, Jean-Pierre Gangneux1, and Fanny LanternierComments to Author 
Author affiliation: Hopital Necker-Enfants Malades, Paris, France (L. Bertin-Biasutto, O. Paccoud, O. Lortholary, F. Lanternier); Université de Paris, Paris (L. Bertin-Biasutto, O. Lortholary, F. Lanternier); Institut Pasteur, Paris (D. Garcia-Hermoso, K. Boukris-Sitbon, O. Lortholary, S. Bretagne, A. Alanio, F. Lanternier); Hôpital Saint Louis, Paris (B. Denis, S. Bretagne, M. Gits-Muselli, A. Aliano); Institut de Cancérologie de Strasbourg, Strasbourg, France (R. Herbrecht); Hôpitaux Universitaires de Strasbourg, Strasbourg (V. Letscher-Bru, F. Danion); Toulouse University Hospital, Toulouse, France (S. Cassaing); Nantes University Hospital, Nantes, France (F. Morio); CHU Clermont-Ferrand, Clermont-Ferrand, France (C. Nourrisson); CHU d'Angers, Angers, France (M. Pihet); CHU Nîmes and Université de Montpellier, Nîmes, France (M. Sasso); Hôpital Bretonneau, Tours, France (G. Desoubeaux); Limoges University, Limoges, France (M.-F. Durieux); Unicaen Université Normandie, Caen, France (J. Bonhomme); Gustave Roussy, Villejuif, France (E. Chachaty); CHU Amiens-Picardie, Amiens, France (T. Chouaki); Inserm U1285, University of Lille, Lille, France (T. Chouaki); Centre Hospitalier Universitaire de Martinique, Fort-de-France, France (N. Desbois-Nogard); Université de Rennes, CHU Rennes, Rennes, France (J.-P. Gangneux); Rennes Teaching Hospital, Rennes (J.-P. Gangneux)

Main Article

Table 4

Main characteristics of patients with disseminated infections in a study of features of invasive aspergillosis caused by Aspergillus flavus, France, 2012–2018*

Characteristics
 Value
Median age, y (IQR)
 36 (14.5–58)
Sex
M 3 (42.8)
F
 4 (57.1)
Main risk factor
Hematologic malignancy 4 (57.1)
Solid organ cancer 1 (14.3)
Solid organ transplant 1 (14.3)
Others, severe burns
 1 (14.3)
Fever as primary clinical sign
 5 (71.4)
Site of infection
Pulmonary 6 (85.7)
Ear, nose, throat 2 (28.6)
Central nervous system 2 (28.6)
Skin and soft tissues 3 (42.8)
Fungemia
 2 (28.6)
Median time to diagnosis, d (IQR)
 5 (4.5–28)
Positive serum galactomannan antigen, n = 5
 5 (100)
Proven cases
 5 (71.4)
Fungal co-infection
 3 (42.8)
Voriconazole first-line antifungal therapy
 6 (85.7)
3-month case-fatality 4 (57.1)

*IQR, interquartile range.

Main Article

1These authors contributed equally contributed to this article.

Page created: March 19, 2025
Page updated: April 29, 2025
Page reviewed: April 29, 2025
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