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Volume 20, Number 8—August 2014
Dispatch

New Introductions of Enterovirus 71 Subgenogroup C4 Strains, France, 2012

Isabelle SchuffeneckerComments to Author , Cécile Henquell, Audrey Mirand, Marianne Coste-Burel, Stéphanie Marque-Juillet, Delphine Desbois, Gisèle Lagathu, Laure Bornebusch, Jean-Luc Bailly, and Bruno Lina
Author affiliations: Hospices Civils de Lyon, Lyon, France (I. Schuffenecker, B. Lina); Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont-Ferrand, France (C. Henquell, A. Mirand); Université d’Auvergne, Clermont-Ferrand (C. Henquell, A. Mirand, J.-L. Bailly); Centre Hospitalier Universitaire de Nantes, Nantes, France (M. Coste-Burel); Centre Hospitalier de Versailles, Le Chesnay, France (S. Marque-Juillet); Centre Hospitalier de Rambouillet, Rambouillet, France (D. Desbois); Centre Hospitalier Universitaire de Rennes, Rennes, France (G. Lagathu); Centre Hospitalier de Grasse, Grasse, France (L. Bornebusch)

Main Article

Table

Characteristics of 4 patients with enterovirus 71 subgenogroup C4 infections, France, 2012*

Patient no., hospital location† Date admitted Age at diagnosis Clinical signs Laboratory values for CSF
 Enterovirus RT-PCR results, Ct‡
 Duration, d
Leukocytes/ mm3 Protein, g/L CSF NP Hospital stay Antimicrobial drug use
1, Nantes Feb 12 6 d Fever syndrome <2 0.54 Pos, 36.0 Pos, 36.2 4.0 4.0
2, Versailles Mar 12 17 d Fever syndrome 53 0.52 Pos, 31.7 NA 2.5 2.5
3, Grasse Jun 12 4.5 y Fever syndrome, meningitis 83§ 0.92§ Neg Pos, 27.4 1.0 0
4, Rennes Oct 12 21 d Fever syndrome, rhinitis 234 0.77 Pos, 30.0 NA 6.0 3.0

*For all 4 children, molecular testing results were negative for the detection of herpes simplex virus types 1 and 2 and varicella-zoster virus in CSF. In addition, for patients 1 and 4, molecular testing results were also negative for the detection of human herpesvirus type 6, cytomegalovirus, and Epstein-Barr virus. Results were also negative for CSF bacterial cultures. CSF, cerebrospinal fluid sample; Ct, cycle threshold; NA, not available; Neg, negative NP, nasopharyngeal sample; Pos, positive; RT-PCR, reverse transcription PCR.
†Nantes (47°13′N; 1°33′W; Brittany); Versailles (48°48′N; 2°08′E; Ile de France); Grasse (43°40′N; 6°55′E; Provence-Alpes-Côte d’Azur); Rennes (48°06′N; 1°40′W; Brittany).
‡The upper Ct for positivity for each of the RT-PCR assays used was 45.0. An in-house enterovirus real-time RT-PCR was used to test samples from patient 1. A commercial RT-PCR assay produced by Cepheid and commercialized by Orgentec (GP-EV-040, Orgentec, Trappes, France) was used to test samples from patients 2 and 3. Another commercial RT-PCR assay, Dia-ENT-050 (Diagenode, Seraing, Belgium) was used to test samples from patient 4.
§CSF sample was hemorrhagic (10,300 erythrocytes/mm3).

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Page created: July 18, 2014
Page updated: July 18, 2014
Page reviewed: July 18, 2014
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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