Volume 21, Number 11—November 2015
Research
Serotype Changes and Drug Resistance in Invasive Pneumococcal Diseases in Adults after Vaccinations in Children, Japan, 2010–2013
Kimiko Ubukata
, Naoko Chiba, Shigeo Hanada, Miyuki Morozumi, Takeaki Wajima, Michi Shouji, Satoshi Iwata, and Invasive Pneumococcal Diseases Surveillance Study Group
, Naoko Chiba, Shigeo Hanada, Miyuki Morozumi, Takeaki Wajima, Michi Shouji, Satoshi Iwata, and Invasive Pneumococcal Diseases Surveillance Study Group
Table 3
Isolates positive for invasive pneumococcal diseases in adults, by age group, Japan, April 2010–March 2013
| Disease | No. (%) | Mean age, y (±SD) |
p value |
|||||
|---|---|---|---|---|---|---|---|---|
| Total |
19–49 |
50–64 |
65–74 |
75–84 |
>85 |
|||
| Pneumonia* | 375 (52.4) | 33 (39.8) | 66 (42.0) | 103 (49.8) | 105 (60.7) | 68 (71.6) | 74 (14.9) | <0.001 |
| Bacteremia and sepsis† | 172 (24.1) | 20 (24.1) | 42 (26.8) | 55 (26.6) | 34 (19.7) | 21 (22.1) | 70 (15.0) | 0.497 |
| Meningitis | 127 (17.8) | 24 (28.9) | 38 (24.2) | 37 (17.9) | 22 (12.7) | 6 (6.3) | 65 (14.4) | <0.001 |
| Other‡ |
41 (5.7) |
6 (7.2) |
11 (7.0) |
12 (5.8) |
12 (6.9) |
0 |
67 (14.5) |
0.133 |
| Total | 715 | 83 | 157 | 207 | 173 | 95 | 70 (14.9) | |
*Includes empyema (n = 17) and pleuritis (n = 16).
†Bacteremia (n = 39), sepsis (n = 51), severe sepsis (n = 58), and septic shock (n = 24).
‡Cellulitis (n = 7), arthritis (n = 6), spondylitis (n = 4), peritonitis (n = 3), and other conditions.
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