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Volume 26, Number 3—March 2020
Research

Pregnancy Outcomes among Women Receiving rVSVΔ-ZEBOV-GP Ebola Vaccine during the Sierra Leone Trial to Introduce a Vaccine against Ebola

Jennifer K. Legardy-Williams1Comments to Author , Rosalind J. Carter1, Susan T. Goldstein, Olamide D. Jarrett, Elena Szefer, Augustin E. Fombah, Sarah C. Tinker, Mohamed Samai2, and Barbara E. Mahon2
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (J.K. Legardy-Williams, R.J. Carter, S.T. Goldstein, O.D. Jarrett, S.C. Tinker, B.E. Mahon); University of Illinois at Chicago, Chicago, Illinois, USA (O.D. Jarrett); The Emmes Corporation (E. Szefer); University of Sierra Leone College of Medicine and Allied Health Sciences, Freetown, Sierra Leone (A.E. Fombah, M. Samai)

Main Article

Table 1

Demographic characteristics and pregnancy outcomes by vaccination group among 84 women with estimated date of conception <60 days from vaccination or enrollment, Sierra Leone Trial to Introduce a Vaccine against Ebola*

Characteristic Immediate vaccinated Unvaccinated Deferred crossover vaccinated Total
Total
 31
 35
 18
 84
Median age, y (range)
 27 (22–38)
 29 (20–40)
 28 (20–38)
 28 (20–40)
Primary occupation
Nurse† 24 (77) 29 (83) 13 (72) 66 (79)
Frontline worker 5 (16) 6 (17) 3 (17) 14 (16)
Other‡
 2 (7)
 0
 2 (11)
 4 (5)
Prior pregnancy
No 10 (32) 12 (34) 6 (33) 28 (33)
Yes
 21 (68)
 23 (66)
 12 (67)
 56 (67)
Pregnancy outcomes
Known 31 (100) 33 (94) 17 (94) 81 (96)
Live birth 17 (55) 22 (66)§ 12 (71)§ 51 (63)
Preterm delivery 2 0 0 2
Term delivery 15 22 12 49
Pregnancy loss¶ 14 (45) 11 (33)§ 5 (29)§ 30 (37)
Unknown 0 2 (6) 1 (6) 3 (4)

*Values are no. (%) except as indicated.
†Includes nurse, nurse aide, maternal–child health aide, nursing student, midwife, community health nurse, and vaccinator.
‡Includes allied health profession, community health worker, dentist, medical counselor, nutritionist, physiotherapist, vaccinator, and surveillance worker.
§Denominator for live birth and pregnancy loss includes number of pregnancies with known outcomes (i.e., unknown outcomes excluded).
¶Pregnancy loss includes spontaneous abortion and stillbirth.

Main Article

1These first authors contributed equally to this article.

2These authors were co–principal investigators.

Page created: February 20, 2020
Page updated: February 20, 2020
Page reviewed: February 20, 2020
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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