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Volume 30, Number 1—January 2024
Research

Disease-Associated Streptococcus pneumoniae Genetic Variation

Shimin Yang1, Jianyu Chen1, Jinjian Fu1, Jiayin Huang, Ting Li, Zhenjiang Yao, and Xiaohua YeComments to Author 
Author affiliations: Guangdong Pharmaceutical University, Guangzhou, China (S. Yang, J. Chen, J. Huang, T. Li, Z. Yao, X. Ye); Liuzhou Maternity and Child Health Care Hospital, Liuzhou, China (J. Fu)

Main Article

Table 2

Resubstitution estimate and cross-validation results based on random forest models used in study of disease-associated Streptococcus pneumoniae genetic variation*

Evaluation indicators 10,713 k-mer predictors
 886 k-mer predictors
 8 k-mer predictors
Resubstitution estimate 10-fold cross-validation estimate Resubstitution estimate 10-fold cross-validation estimate Resubstitution estimate 10-fold cross-validation estimate
Accuracy 98.60 93.23 96.42 90.81 90.93 90.04
Balanced accuracy 98.65 93.60 96.61 91.28 91.48 90.89
Sensitivity 99.13 94.48 97.91 92.87 94.27 93.72
Specificity 98.18 92.71 95.31 89.69 88.70 88.07
PPV 97.71 90.27 93.98 86.27 84.81 83.65
NPV 99.31 95.63 98.39 94.48 95.85 95.18
Kappa 0.97 0.86 0.93 0.81 0.81 0.80

*Values are percentages except for kappa, which is reported as a value ranging from –1 to 1. NPV, negative predictive value; PPV, positive predicitive value.

Main Article

1These authors contributed equally to this article.

Page created: November 24, 2023
Page updated: December 20, 2023
Page reviewed: December 20, 2023
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