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Volume 30, Number 9—September 2024
Dispatch

Cocirculation of Genetically Distinct Highly Pathogenic Avian Influenza H5N5 and H5N1 Viruses in Crows, Hokkaido, Japan

Yik Lim Hew, Takahiro HionoComments to Author , Isabella Monne, Kei Nabeshima, Saki Sakuma, Asuka Kumagai, Shunya Okamura, Kosuke Soda, Hiroshi Ito, Mana Esaki, Kosuke Okuya, Makoto Ozawa, Toshiyo Yabuta, Hiroki Takakuwa, Linh Bao Nguyen, Norikazu Isoda, Kohtaro Miyazawa, Manabu Onuma, and Yoshihiro Sakoda
Author affiliations: Hokkaido University, Sapporo, Japan (Y.L. Hew, T. Hiono, L.B. Nguyen, N. Isoda, Y. Sakoda); Istituto Zooprofilattico Sperimentale delle Venezie, Padova, Italy (I. Monne); National Institute for Environmental Studies, Tsukuba, Japan (K. Nabeshima, M. Onuma); National Agriculture and Food Research Organization, Tsukuba (S. Sakuma, A. Kumagai, K. Miyazawa); Tottori University, Tottori, Japan (S. Okamura, K. Soda, H. Ito); Kagoshima University, Kagoshima, Japan (M. Esaki, K. Okuya, M. Ozawa); Kyoto Sangyo University, Kyoto, Japan (T. Yabuta, H. Takakuwa)

Main Article

Table 2

BLAST search results of H5N5 HPAIVs isolated in Japan in winter 2023–24 in study of cocirculation of genetically distinct H5N5 and H5N1 HPAIVs in crows, Hokkaido, Japan*

Virus name Gene Most homologous strain Homology, % Accession no.
A/large-billed crow/Hokkaido/B073/2024 (H5N5)†
 PB2 A/Common eider/Iceland/2023AI08561/2023 (H5N5) 99.7 EPI2791002
PB1 A/Common eider/ Iceland/2023AI08561/2023 (H5N5) 99.8 EPI2791003
PA A/Common eider/ Iceland/2023AI08561/2023 (H5N5) 99.7 EPI2791001
HA A/Common gull/England/129428/2023 (H5N5) 99.8 EPI2815885
NP A/Herring gull/England/404384/2023 (H5N5) 99.9 EPI2815894
NA A/Herring gull/England/404384/2023 (H5N5) 99.5 EPI2815900
M A/Herring gull/England/404384/2023 (H5N5) 99.9 EPI2815896
NS
 A/Herring gull/England/404384/2023 (H5N5)
 99.9
 EPI2815895
A/peregrine falcon/Kumamoto/4301C001/2024 (H5N5)‡ PB2 A/large-billed crow/Hokkaido/20231207001/2023 (H5N1) 99.9 EPI2898966
PB1 A/large-billed crow/Hokkaido/20231207001/2023 (H5N1) 99.9 EPI2898967
PA A/large-billed crow/Hokkaido/0111Q100/2023 (H5N1) 99.8 EPI2841124
HA A/large-billed crow/Hokkaido/20231207001/2023 (H5N1) 99.9 EPI2898969
NP A/large-billed crow/Hokkaido/0112Q104/2023 (H5N1) 99.7 EPI2815894
NA A/Duck/Hokkaido/W24/ 2020 (H6N5) 99.1 EPI1896526
M A/large-billed crow/Hokkaido/20231207001/2023 (H5N1) 100 EPI2815896
NS A/large-billed crow/Hokkaido/20231207001/2023 (H5N1) 99.9 EPI2898973

*Gene segment sequences of 2 H5N5 HPAIVs were compared with those of other H5 virus sequences by using BLAST (https://blast.ncbi.nlm.nih.gov). Accession numbers are from GISAID (https://www.gisaid.org). HA, hemagglutinin; HPAIV, highly pathogenic avian influenza virus; M, matrix protein; NA, neuraminidase; NP, nucleoprotein; NS, nonstructural protein; PA, polymerase acidic; PB1, polymerase basic 1; PB2, polymerase basic 2. †H5N5 HPAIV isolated in Hokkaido in winter 2023–24. ‡H5N5 HPAIV isolated in Kumamoto Prefecture in winter 2023–24.

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Page created: July 08, 2024
Page updated: August 21, 2024
Page reviewed: August 21, 2024
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