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Volume 31, Number 5—May 2025
Dispatch

Tropheryma whipplei Infections, Mexico, 2019–2021

Jesús Delgado-de la Mora1Comments to Author , Peter Grube-Pagola1, Christopher D. Paddock, Marlene DeLeon-Carnes, Alvaro C. Laga, Isaac H. Solomon, José María Remes-Troche, Jesús Javier Baquera-Heredia, Gabriel Quintero-Bustos, Juan Carlos León-Contreras, Arturo Ángeles-Ángeles, and Braulio Martínez-Benítez
Author affiliation: Weill-Cornell Medicine, New York, New York, USA (J. Delgado-de la Mora); Instituto de Investigaciones Médico Biológicas de la Universidad Veracruzana, Veracruz, Mexico (P. Grube-Pagola, J.M. Remes-Troche); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (C.D. Paddock, M. DeLeon-Carnes); Brigham and Women’s Hospital, Boston, Massachusetts, USA (A.C. Laga, I.H. Solomon); Centro Médico ABC, Mexico City, Mexico (J.J. Baquera-Heredia); Laboratorio Flemming, Morelos, Mexico (G. Quintero-Bustos); Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City (J.C. León-Contreras, A. Ángeles-Ángeles, B. Martínez-Benítez).

Main Article

Figure 2

Microscopic and immunohistochemical examination of tissue samples from the ileum in a a 45-year-old man with Tropheryma whipplei infection, Mexico, 2021. A, B) Hematoxylin and eosin–stained ileum tissue. Microscopic examination showed abundant macrophages in the lamina propria with foamy cytoplasm (A; original magnification ×4); and intracytoplasmic inclusions that were intensely PAS-positive (B; original magnification ×40). C, D) Electron microscopy showing rod-shaped T. whipplei in the lamina propria of ileum (C; scale bar = 1 μm), and trilaminar plasma membranes in macrophages (D; scale bar = 200 nm).

Figure 2. Microscopic and immunohistochemical examination of tissue samples from the ileum in a a 45-year-old man with Tropheryma whipplei infection, Mexico, 2021. A, B) Hematoxylin and eosin–stained ileum tissue. Microscopic examination showed abundant macrophages in the lamina propria with foamy cytoplasm (A; original magnification ×4); and intracytoplasmic inclusions that were intensely PAS-positive (B; original magnification ×40). C, D) Electron microscopy showing rod-shaped T. whipplei in the lamina propria of ileum (C; scale bar = 1 μm), and trilaminar plasma membranes in macrophages (D; scale bar = 200 nm).

Main Article

1These authors contributed equally to this article.

Page created: March 10, 2025
Page updated: April 22, 2025
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