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Volume 30, Number 10—October 2024
Research

Pathogenicity of Highly Pathogenic Avian Influenza A(H5N1) Viruses Isolated from Cats in Mice and Ferrets, South Korea, 2023

Il-Hwan Kim1, Jeong-Hyun Nam1, Chi-Kyeong Kim, Yong Jun Choi, Hyeokjin Lee, Bo Min An, Nam-Joo Lee, Hyoseon Jeong, Su-Yeon Lee, Sang-Gu Yeo, Eun-Kyoung Lee, Youn-Jeong Lee, Jee Eun Rhee, Sang Won Lee, Youngmee Jee, and Eun-Jin KimComments to Author 
Author affiliations: Korea Disease Control and Prevention Agency, Cheongju, South Korea (I.-H. Kim, J.-H. Nam, C.-K. Kim, Y.J. Choi, H. Lee, B.M. An, N.-J. Lee, H. Jeong, S.-Y. Lee, S.-G. Yeo, J.E. Rhee, S.W. Lee, Y. Jee, E.-J. Kim); Animal and Plant Quarantine Agency, Gimcheon, South Korea (E.-K. Lee, Y.-J. Lee)

Main Article

Table 2

Comparisons of major amino acid substitutions in protein segments from highly pathogenic avian influenza A(H5N1) viruses isolated from cats, South Korea, 2023*

Virus HA†
 PB2‡
 NA§
 M¶
123 133 156 222 224 526 591 627 701 274 31
A/duck/Korea/H493/2022 P A A Q G K Q E D H S
A/feline/Korea/M302-6/2023 P A A Q G K Q E N H S
A/feline/Korea/M305-7/2023 P A A Q G K Q K D H S

*Bold letters indicate substitutions in each virus protein. HA, hemagglutinin; M, matrix protein; NA, neuraminidase; PB2, polymerase basic protein 2. †H5 numbering was used. S123P, S133A, T156A, Q222L, and G224S affect α2,6-sialic acid receptor binding affinity. ‡K526R, Q591K, E627K, and D701N enhance virus replication in mammals. §H274Y affects inhibition of NA. ¶S31N affects matrix protein inhibition.

Main Article

1These authors contributed equally to this article.

Page created: August 21, 2024
Page updated: September 23, 2024
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