Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link

Disclaimer: Early release articles are not considered as final versions. Any changes will be reflected in the online version in the month the article is officially released.

Volume 30, Number 10—October 2024
Research

Pathogenicity of Highly Pathogenic Avian Influenza A(H5N1) Viruses Isolated from Cats in Mice and Ferrets, South Korea, 2023

Il-Hwan Kim1, Jeong-Hyun Nam1, Chi-Kyeong Kim, Yong Jun Choi, Hyeokjin Lee, Bo Min An, Nam-Joo Lee, Hyoseon Jeong, Su-Yeon Lee, Sang-Gu Yeo, Eun-Kyoung Lee, Youn-Jeong Lee, Jee Eun Rhee, Sang Won Lee, Youngmee Jee, and Eun-Jin KimComments to Author 
Author affiliations: Korea Disease Control and Prevention Agency, Cheongju, South Korea (I.-H. Kim, J.-H. Nam, C.-K. Kim, Y.J. Choi, H. Lee, B.M. An, N.-J. Lee, H. Jeong, S.-Y. Lee, S.-G. Yeo, J.E. Rhee, S.W. Lee, Y. Jee, E.-J. Kim); Animal and Plant Quarantine Agency, Gimcheon, South Korea (E.-K. Lee, Y.-J. Lee)

Main Article

Table 2

Comparisons of major amino acid substitutions in protein segments from highly pathogenic avian influenza A(H5N1) viruses isolated from cats, South Korea, 2023*

Virus HA†
 PB2‡
 NA§
 M¶
123 133 156 222 224 526 591 627 701 274 31
A/duck/Korea/H493/2022 P A A Q G K Q E D H S
A/feline/Korea/M302-6/2023 P A A Q G K Q E N H S
A/feline/Korea/M305-7/2023 P A A Q G K Q K D H S

*Bold letters indicate substitutions in each virus protein. HA, hemagglutinin; M, matrix protein; NA, neuraminidase; PB2, polymerase basic protein 2. †H5 numbering was used. S123P, S133A, T156A, Q222L, and G224S affect α2,6-sialic acid receptor binding affinity. ‡K526R, Q591K, E627K, and D701N enhance virus replication in mammals. §H274Y affects inhibition of NA. ¶S31N affects matrix protein inhibition.

Main Article

1These authors contributed equally to this article.

Page created: August 21, 2024
Page updated: September 06, 2024
Page reviewed: September 06, 2024
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external