Volume 30, Number 10—October 2024
Research
Pathogenicity of Highly Pathogenic Avian Influenza A(H5N1) Viruses Isolated from Cats in Mice and Ferrets, South Korea, 2023
Table 3
Virus | Subtype | Neuraminidase inhibitors |
|||||||
---|---|---|---|---|---|---|---|---|---|
Oseltamivir |
Zanamivir |
Peramivir |
|||||||
IC50, nM | Fold change | IC50, nM | Fold change | IC50, nM | Fold change | ||||
A/duck/Korea/H493/2022 | H5N1 | 0.16 | 0.11 | 0.19 | 0.18 | 0.44 | 0.775 | ||
A/feline/Korea/M302-6/2023 | H5N1 | 0.35 | 0.24 | 0.18 | 0.17 | 0.2 | 0.3 | ||
A/feline/Korea/M305–/2023 | H5N1 | 0.23 | 0.15 | 0.16 | 0.15 | 0.2 | 0.36 | ||
Influenza A(H1N1)pdm09 | H1N1 | 1.47 | 1 | 1.09 | 1 | 0.57 | 1 |
*H5N1 virus from 1 duck was compared with 2 viruses isolated from cats. Fold change in drug susceptibility was measured relative to that of influenza A(H1N1)pdm09 containing the wild-type H274 amino acid in neuraminidase. IC50, 50% inhibitory concentration.
1These authors contributed equally to this article.
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