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Volume 26, Number 11—November 2020
Research

Modeling Treatment Strategies to Inform Yaws Eradication

Alex HolmesComments to Author , Michael J. Tildesley, Anthony W. Solomon, David C.W. Mabey, Oliver Sokana, Michael Marks, and Louise Dyson
Author affiliations: Mathematics Institute, University of Warwick, Coventry, UK (A. Holmes, M.J. Tildesley, L. Dyson); University of Warwick School of Life Sciences, Coventry (M.J. Tildesley, L. Dyson); Hospital for Tropical Diseases, London, UK (A.W. Solomon, D.C.W. Mabey, M. Marks); London School of Hygiene and Tropical Medicine, London (A.W. Solomon, D.C.W. Mabey, M. Marks); Ministry of Health and Medical Services, Honiara, Solomon Islands (O. Sokana)

Main Article

Table 1

Permitted state transitions and state transition rates for steady state household model of yaws transmission*

Description State transition Rate
Infection, external (ε) and within-household (β) (S,I,A) ® (S-1,I+1,A)
Treatment/birth-death (S,I,A) ® (S+1,I-1,A) δ
Remission (S,I,A) ® (S,I-1,A+1) λ
Recurrence (S,I,A) ® (S,I+1,A-1) ρ
Treatment/birth-death (S,I,A) ® (S+1,I,A-1) δ

*Methods described in Appendix . A, asymptomatically infected (but not infectious); I, infected and infectious; S, susceptible.

Main Article

Page created: August 18, 2020
Page updated: October 17, 2020
Page reviewed: October 17, 2020
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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