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Volume 31, Number 4—April 2025
Research

Carbapenem-Resistant, Virulence Plasmid–Harboring Klebsiella pneumoniae, United States

Jianping Jiang, Tengfei Long, Adeline R. Porter, Arianne Lovey, Annie Lee, Jesse Thomas Jacob, Cesar A. Arias, Robert Bonomo, Robert Kalayjian, Yanan Zhao, Frank R. DeLeo, David van Duin, Barry N. KreiswirthComments to Author , and Liang ChenComments to Author 
Author affiliation: Hackensack-Meridian Health Center for Discovery and Innovation, Nutley, New Jersey, USA (J. Jiang, T. Long, A. Lovey, A. Lee, Y. Zhao, B.N. Kreiswirth, L. Chen); National Institute of Allergy and Infectious Disease Rocky Mountain Laboratories, Hamilton, Montana, USA (A.R. Porter, F.R. DeLeo); Emory University, Atlanta, Georgia, USA (J.T. Jacob); Houston Methodist Hospital and Houston Methodist Research Institute, Houston, Texas, USA (C.A. Arias); Louis Stokes Cleveland VA Medical Center, Cleveland, Ohio, USA (R.A. Bonomo); Case Western Reserve University School of Medicine, Cleveland (R.A. Bonomo); MetroHealth Medical Center, Cleveland (R. Kalayjian); University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA (D. van Duin)

Main Article

Figure 1

Information of 884 isolates of carbapenem-resistant Klebsiella pneumoniae isolates, United States. A) Unadjusted distribution of desirability of outcome ranking outcomes. B) Heatmap of infections, virulence genes, antimicrobial resistance genes, and porin mutations in STs with >2 isolates. *MgrB or PmrB loss-of-function mutations. #Mutations in the quinolone resistance–determining regions of GyrA and ParC. C) Distribution of drug classes by genome for which antimicrobial resistance elements were detected. Bars colors indicate the presence of virulence genes. D, E) Distributions of virulence genes (D) and virulence gene combination (E) per genomes. Bars are colored based on STs. ESBL, extended-spectrum β-lactamase; ST, sequence type.

Figure 1. Information of 884 isolates of carbapenem-resistant Klebsiella pneumoniae isolates, United States. A) Unadjusted distribution of desirability of outcome ranking outcomes. B) Heatmap of infections, virulence genes, antimicrobial resistance genes, and porin mutations in STs with >2 isolates. *MgrB or PmrB loss-of-function mutations. #Mutations in the quinolone resistance–determining regions of GyrA and ParC. C) Distribution of drug classes by genome for which antimicrobial resistance elements were detected. Bars colors indicate the presence of virulence genes. D, E) Distributions of virulence genes (D) and virulence gene combination (E) per genomes. Bars are colored based on STs. ESBL, extended-spectrum β-lactamase; ST, sequence type.

Main Article

Page created: February 18, 2025
Page updated: March 11, 2025
Page reviewed: March 11, 2025
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