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Volume 31, Number 4—April 2025
Research

Carbapenem-Resistant, Virulence Plasmid–Harboring Klebsiella pneumoniae, United States

Jianping Jiang, Tengfei Long, Adeline R. Porter, Arianne Lovey, Annie Lee, Jesse Thomas Jacob, Cesar A. Arias, Robert Bonomo, Robert Kalayjian, Yanan Zhao, Frank R. DeLeo, David van Duin, Barry N. KreiswirthComments to Author , and Liang ChenComments to Author 
Author affiliation: Hackensack-Meridian Health Center for Discovery and Innovation, Nutley, New Jersey, USA (J. Jiang, T. Long, A. Lovey, A. Lee, Y. Zhao, B.N. Kreiswirth, L. Chen); National Institute of Allergy and Infectious Disease Rocky Mountain Laboratories, Hamilton, Montana, USA (A.R. Porter, F.R. DeLeo); Emory University, Atlanta, Georgia, USA (J.T. Jacob); Houston Methodist Hospital and Houston Methodist Research Institute, Houston, Texas, USA (C.A. Arias); Louis Stokes Cleveland VA Medical Center, Cleveland, Ohio, USA (R.A. Bonomo); Case Western Reserve University School of Medicine, Cleveland (R.A. Bonomo); MetroHealth Medical Center, Cleveland (R. Kalayjian); University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA (D. van Duin)

Main Article

Table 1

Characteristics of case-patients in study of carbapenem-resistant, virulence plasmid–harboring Klebsiella pneumoniae isolates, United States*

Patient characteristic Isolate
ARLG-4622 ARLG-3254 ARLG-4744 ARLG-7683 ARLG-3484 ARLG-4720
Location Cleveland, OH Houston, TX Atlanta, GA Atlanta, GA Atlanta, GA Atlanta, GA
Hospital Hospital A Hospital B Hospital C Hospital C Hospital C Hospital C
Department Emergency department Medical ward Medical ward Surgery ward ICU ICU
Collection date
2016 Jun
2016 Sep
2017 Jul
2017 Oct
2016 Dec
2017 Mar
Age group at culture, y 39<49 49<59 49<59 59<69 69<79 49<59
Sex
F
M
M
M
M
M
Hospital or community acquired Hospital Community Hospital Community Hospital Hospital
Culture source Urine Respiratory Urine Wound Respiratory Respiratory
Other pathogens from same source
None
None
None
None
None
None
Infection vs. colonization
Infection
Infection
Infection
Colonization
Colonization
Colonization
Charlson Comorbidity Index score 0 3 4 1 8 1
Pitt bacteremia score
0
3
8
2
6
4
DOOR outcomes Alive without events Dead Dead Alive without events Alive with 2 or 3 events Alive without events

*DOOR, desirability of outcome ranking; ICU, intensive care unit.

Main Article

Page created: February 18, 2025
Page updated: March 11, 2025
Page reviewed: March 11, 2025
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